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Roles of traditional Chinese medicine extracts in hyperuricemia and gout treatment: Mechanisms and clinical applications.
World J Gastroenterol
December 2024
Department of Cell Biology, Jinan Microecological Biomedicine Shandong Laboratory, Jinan 250117, Shandong Province, China.
In this manuscript, we comment on the article by Liu published in the recent issue of the journal. Hyperuricemia (HUA) has become the second most common metabolic disease after type 2 diabetes mellitus and is the most important risk factor for gout. This discussion focuses on the targets and clinical application value of traditional Chinese medicine (TCM) extracts in the treatment of HUA and gout, emphasizing the role of gut microbiota.
View Article and Find Full Text PDFReply to Comment on "Fast and accurate electromagnetic field calculation for substrate-supported metasurfaces using the discrete dipole approximation".
Nanophotonics
July 2024
Wyant College of Optical Sciences, University of Arizona, 1630 E University Blvd, Tucson, AZ 85719, USA.
The recent comment on our previously published article questioned the novelty and computational efficiency of our work. Here we respond by restating the novelty and scientific value of our work as well as showing why the specific alternative methods stated in the comment are unlikely to outperform the methods we compare for metasurface applications involving high refractive index particles near high refractive index substrates.
View Article and Find Full Text PDFRandomised Badger Culling Trial lacks evidence for proactive badger culling effect on tuberculosis in cattle: comment on Mills et al. 2024, Parts I & II.
bioRxiv
September 2024
Herpetofauna Consultants International, Suffolk, UK.
Article Synopsis
- The rebuttal by Mills et al. (2024) defends the statistical methods used in the Randomised Badger Culling Trial (RBCT), particularly the choice of count over rate for assessing bovine tuberculosis herd incidence.
- * The authors argue that previous analyses overfit data and incorrectly apply Bayesian methods, prioritizing model fit over practical predictive power in a small dataset context.
- * Ultimately, the RBCT's findings on the impact of badger culling on bovine tuberculosis incidence are deemed unconvincing, with modern veterinary insights suggesting the original conclusions still stand but require a nuanced understanding.
Response to: Reflections on 'Have we lost sleep?'.
Med Hist
July 2024
School of Creative Arts, Culture and Communication, Birkbeck University of London, London, United Kingdom of Great Britain and Northern Ireland.
I would like to thank Professor Ekirch for his reflections on 'Have we lost sleep?', which contain several points that I have already responded to within the paper following his peer review of my original submission to in 2023 (Professor Ekirch having voluntarily identified himself as a reviewer in a normally double-blind process). I acknowledge that the focus of my paper was on Ekirch's original work from 2001; if I did not engage as he would have wished with his subsequent publications, this was simply because I do not perceive the same substantial developments in his thinking and research on the subject that he does. Indeed, the present critique by Ekirch amounts essentially to more of the same: a long list of references and quotes but little detailed discussion of any individual source.
View Article and Find Full Text PDF[CFTR gene variant screening in gamete donation candidates in France: Which indications? How to screen? Why?].
Gynecol Obstet Fertil Senol
January 2025
Service de biologie de la reproduction-CECOS, CHU de Bordeaux, Bordeaux, France; Bordeaux Institute in Oncology - BRIC - équipe BioGo, Inserm U1312, université de Bordeaux, Bordeaux, France.
Objectives: According to French recommendations, only the caryotype is carried out as a first line in candidates for gamete donation. The prescription of additional genetic tests for variants responsible for serious monogenic diseases is only recommended in the case of call points. However, cystic fibrosis remains the most common genetic disease with serious consequences in childhood.
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