Intracranial lipomas are rare congenital malformations that can often be seen in association with other brain malformations; agenesis or dysgenesis of the corpus callosum is the most frequently associated brain anomaly. They are usually pericallosal asymptomatic midline lesions. Intracranial lipomas associated with a non-contiguous cerebral aneurysm are extremely rare. We report an infant with partial agenesis of the corpus callosum and pericallosal lipoma associated with cerebral haemorrhage due to a distal middle cerebral artery aneurysm. Such an association is probably not fortuitous and could suggest a pathogenic relationship.
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Department of Neurosurgery, Mohammed VI University Hospital Center of Marrakesh, Cadi Ayyad University, Faculty of Medicine, Marrakesh, Morocco.
Background: Intracranial lipomas are a rare clinical entity. These lesions are frequently asymptomatic and originate in the pericallosal area. As they are fat-containing lesions which are intimately attached to the surrounding structures, surgery is not recommended.
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Lipoma of the corpus callosum, also known as pericallosal lipoma, is a rare congenital brain abnormality associated with corpus callosum dysgenesis or agenesis. Two morphological types are described: tubulonodular and curvilinear, with the latter being mostly asymptomatic. We present the case of a 30-year-old woman with epilepsy, whose magnetic resonance imaging revealed a "caterpillar sign" in the corpus callosum associated with a curvilinear pericallosal lipoma.
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Article Synopsis
- The study aimed to compare imaging and genetic findings in fetuses with corpus callosum abnormalities identified through prenatal exome sequencing (pES) between 2018 and 2020.
- A total of 113 fetuses were included, revealing pathogenic/likely pathogenic (P/LP) genetic variants in certain types of abnormalities, with significant findings in cases with associated cerebellar issues.
- The results indicated that P/LP variants were more common in non-isolated conditions and certain types of callosal dysgenesis, but no variants were found for isolated short CC, interhemispheric cysts, or pericallosal lipoma.
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