New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides.

Bioorg Med Chem Lett

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.

Published: March 2010

A new phenylpropanoid conjugated iridoid together with four known congeners was isolated from Morinda morindoides, used for the therapy of malaria traditionally in some African countries, as anti-malarial principles through bioassay-guided separation. Furthermore, their absolute stereostructures were unambiguously established by a combination of modified Mosher's method and chemical correlation.

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http://dx.doi.org/10.1016/j.bmcl.2010.01.095DOI Listing

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