CD56(bright)CD16(-) natural killer (NK) cells that express CXCR3 accumulate in the follicular fluid of patients with a good response to ovarian stimulation. It is conceivable that granulosa cells of good responders that express the chemokine CXCL10 recruit these NK cells to support follicular angiogenesis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.fertnstert.2009.12.067 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Human tissue-resident NK cells in the lung have a higher glycolytic capacity than non-tissue-resident NK cells in the lung and blood.
Proc Natl Acad Sci U S A
October 2024
Department of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, St James' Hospital, Trinity College Dublin, Dublin D08 W9RT, Ireland.
Article Synopsis
- Tissue-resident natural killer (trNK) cells are found in the human lung, and this study investigates their unique metabolic functions, which may play a role in their effectiveness as immune cells.
- Researchers analyzed human bronchoalveolar lavage fluid (BALF) and peripheral blood using flow cytometry and SCENITH to compare the phenotype and metabolism of NK cells in these locations, uncovering specific markers for trNK cells.
- The study discovered that lung NK cells have a significantly higher glycolytic capacity and are more reliant on glucose than those in peripheral blood, suggesting these trNK cells are better equipped to respond to challenges in the lung environment.
Immune cell activity during anti-TNF treatment in patients with psoriasis and psoriatic arthritis.
Clin Exp Immunol
November 2024
Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
Psoriasis is a chronic, inflammatory skin disease characterized by a dysregulated immune response and systemic inflammation. Up to one-third of patients with psoriasis have psoriatic arthritis (PsA). Targeted treatment with antibodies neutralizing tumor necrosis factor can ameliorate both diseases.
View Article and Find Full Text PDFEarly recovery of natural killer cells post T-cell depleted allogeneic stem cell transplantation using alemtuzumab "in the bag".
Transpl Immunol
June 2024
Division of Haematology, Department of Pathology, University of Cape Town, Cape Town, South Africa. Electronic address:
Background: Allogeneic stem cell transplantation (SCT) is a critical therapy for haematological malignancy but may lead to acute and chronic graft versus host disease (GvHD). T-cell depletion with alemtuzumab, either in vivo or ex vivo, reduces the incidence of GvHD but is a risk factor for disease relapse and poor immune reconstitution. Natural killer (NK) cells are the first lymphocytes to recover.
View Article and Find Full Text PDFNK cells and the profile of inflammatory cytokines in the peripheral blood of patients with advanced carcinomas.
Cytokine
February 2024
Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. Electronic address:
Background: Natural killer (NK) cells are one of the most crucial immune cells that mediate the antitumoral response due to their ability to immediately recognize and eliminate transformed cells. Because of their great cytotoxic activity, the function of NK cells must be robustly regulated to avoid tissue damage. Such regulation is mediated by a coordinated engagement of activating (NKp46) and inhibitory (CD158b) receptors, which tumor cells may use to escape from immunosurveillance.
View Article and Find Full Text PDFFunctional TRPA1 Channels Regulate CD56CD16 NK Cell Cytotoxicity against Tumor Cells.
Int J Mol Sci
September 2023
National Institute for Health, Migration and Poverty INMP/NIHMP, Via di S.Gallicano, 25, 00153 Rome, Italy.
Transient receptor potential ankyrin 1 (TRPA1) channels are expressed on the surface of different cell types, including immune cells. However, TRPA1's role in the context of innate and adaptive immune responses has not been fully elucidated so far. In this study, we aimed at investigating the expression and function of TRPA1 channels on NK cells.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!