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Evaluation of the protective role of resveratrol on LPS-induced septic intestinal barrier function via TLR4/MyD88/NF-κB signaling pathways.
Sci Rep
January 2025
Department of Critical Care Medicine, Tongde Hospital of Zhejiang Province, #234 Gucui Road, Hangzhou, 310012, Zhejiang, People's Republic of China.
The intestinal barrier function is a critical defense mechanism in the human body, serving as both the primary target and initiating organ in cases of sepsis. Preserving the integrity of this barrier is essential for preventing complications and diseases, including sepsis and mortality. Despite this importance, the impact of resveratrol on intestinal barrier function remains unclear.
View Article and Find Full Text PDFSynthesis, biological evaluations, and in silico assessments of phenylamino quinazolinones as tyrosinase inhibitors.
Sci Rep
January 2025
Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
A series of novel phenylamino quinazolinone derivatives were designed and synthesized as potential tyrosinase inhibitors. Among these compounds, 9r emerged as the most potent derivative, exhibiting IC values of 17.02 ± 1.
View Article and Find Full Text PDFAmniotic Fluid as a Potential Treatment for Vocal Fold Scar in a Rabbit Model.
J Voice
January 2025
Department of Otolaryngology - Head and Neck Surgery, University of Utah, Salt Lake City, UT; Department of Surgery, University Utah, Salt Lake City, UT.
Objectives/hypothesis: Vocal fold (VF) injury and chronic inflammation can progress to scarring, which is notoriously difficult to treat. Human amniotic fluid (AF) has potential for VF wound healing in a rabbit model, and we hypothesized that AF would demonstrate wound healing properties superior to hyaluronic acid (HA) over time.
Study Design: Randomized, controlled trial.
Extraction of cellulose nanocrystals from date seeds using transition metal complex-assisted hydrochloric acid hydrolysis.
Int J Biol Macromol
January 2025
Chemical and Petroleum Engineering Department, College of Engineering, United Arab Emirates University, PO Box 15551, Al Ain, United Arab Emirates. Electronic address:
In this study, the role of a transition metal complex in improving hydrolysis efficiency during nanocellulose production was analysed. Cellulose nanocrystals (CNCs) were extracted from date seeds by incorporating a copper metal complex during HCl hydrolysis. In contrast to traditional HCl hydrolysis at moderate conditions, which yielded only microcrystalline cellulose (MCC), this approach resulted in the extraction of CNCs with a 10 % improved yield compared to MCC.
View Article and Find Full Text PDFModerate levels of folic acid benefit outcomes for cilia based neural tube defects.
Dev Biol
January 2025
Department of Molecular, Cellular and Development Biology, University of Colorado, Boulder, CO 80309. Electronic address:
Folic acid (FA) supplementation is a potent tool to reduce devastating birth defects known as neural tube defects (NTDs). Though effective, questions remain how FA achieves its protective effect and which gene mutations are sensitive to folic acid levels. We explore the relationship between FA dosage and NTD rates using NTD mouse models.
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