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Orthokids Precise De-rotation Jig for Rotational Osteotomies of Humerus.
Tech Hand Up Extrem Surg
January 2025
Orthokids Clinic, Ahmedabad, Gujarat, India.
Humerus de-rotational osteotomies are one of the commonly done salvage procedures in children with residual brachial plexus birth injuries. Conventionally, the degree of angular correction was measured clinically intraoperatively by the ability to reach the occiput and the belly or it can be measured by putting reference k-wires at the appropriate angles. However, accurate angular correction is essential to success, as under-correction may lead to parental dissatisfaction and over-correction may lead to loss of mid-line function.
View Article and Find Full Text PDFOlive oil and castor oil-based self-nanoemulsifying drug delivery system of flurbiprofen can relieve peripheral pain and inflammation through reduction of oxidative stress and inflammatory biomarkers: a comprehensive formulation and pharmacological insights.
Inflammopharmacology
January 2025
Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, 45210, Pakistan.
Flurbiprofen (FBP) is poorly water-soluble BCS class II drug with anti-inflammatory and analgesic effects, used to treat arthritis and degenerative joint diseases. This study was aimed to develop SNEDDS loaded with FBP. Six SNEDDS using two oils olive oil (F, F, F) and castor oil (F, F, F) with three different Smix ratios consisting of Tween 20 and PEG 400 (1:1, 1:2, 2:1) were prepared and characterized.
View Article and Find Full Text PDFRevision Triceps Reconstruction With Achilles Bone Block Allograft Augmentation: A Novel Inlay Technique.
Tech Hand Up Extrem Surg
January 2025
Department of Orthopaedics, Virginia Commonwealth University Health System, Central Virginia Veteran Affairs Health Care System, Richmond, VA.
Managing rerupture of the triceps brachii tendon after surgical repair is challenging due to poor tissue quality, retraction, and adhesions. This clinical scenario often requires augmentation with native tissue or tendon allografts. Traditional techniques include V-Y advancement, reinforced triceps advancement with double row or suture bridge fixation, and allograft tendon augmentation.
View Article and Find Full Text PDFThe dorsal approach to the middle hepatic vein from the hilar plate in laparoscopic hemihepatectomy (with video).
World J Surg
December 2024
Center for Liver and Pancreatobiliary Cancer, National Cancer Center, Goyang-si, Gyeonggi-do, South Korea.
Background: Although laparoscopic hemihepatectomy has gained prominence, one of the critical challenges in this procedure is the approach to the middle hepatic vein (MHV). The MHV, which runs in the midplane of the liver, is situated above the hilar plate and serves as an anatomical landmark in hemihepatectomy. We have introduced dorsal approach to the MHV from the hilar plate in laparoscopic hemihepatectomy under the laparoscopic caudo-dorsal view.
View Article and Find Full Text PDFDevelopment of a sequential laser microdissection tissue cuts workflow for the spatial and quantitative analysis of drugs in fresh frozen tissue sections.
PLoS One
December 2024
Faculty of Health, Maastricht MultiModal Molecular Imaging Institute (M4I), Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Mass spectrometry imaging (MSI) is a well-established technique that allows to determine the distribution of small molecules, such as lipids, metabolites, and drugs, as well as large molecules in tissue sections. Because of the tissue heterogeneity, resulting in different matrix effects, and to the fact that the measured compounds are not entirely "extracted" from the tissue during the measurement, the absolute quantitative aspect of MSI is limited. To combine compound quantification with spatial information on fresh frozen unstained tissue sections, laser (capture) microdissection has been used to isolate tissue sections for compound extraction and LC-MS/MS quantification.
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