AI Article Synopsis
- A new method for Pd-catalyzed alpha-arylation of ketones with multiple heteroatoms is presented, focusing on a gentle and effective approach.
- The efficiency of the process is influenced by the ratio of ligands to metal and the location of heteroatoms relative to the carbonyl group.
- This method also works for cyclic imines and includes a thorough examination of how various factors, like the ligand to metal ratio, affect the outcomes.
Article Abstract
The development of a general and mild method for Pd-catalyzed alpha-arylation of a variety of ketones bearing multiple heteroatoms is described. The ligand to metal ratio and the position of the heteroatoms with respect to the carbonyl moiety significantly impact the efficiency of these transformations. In addition, these conditions were successfully applied to the alpha-arylation of cyclic imines. A detailed investigation of the scope of this methodology, including the effect of the ligand to metal ratio, is discussed.
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| http://dx.doi.org/10.1021/ol1000318 | DOI Listing |
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