AI Article Synopsis
- This study examines the prevalence and risk factors of intrahepatic cholangiocarcinoma (ICC) in patients aged 40 and younger compared to older patients.
- Young patients showed a lower occurrence of hepatolithiasis but had a higher rate of positive hepatitis B virus markers and associated liver conditions.
- The findings suggest that hepatitis B and its related cirrhosis are significant risk factors for ICC in younger individuals, differing from those in older patients.
Article Abstract
Aim: To investigate the prevalence, risk factors, and clinicopathologic characteristics of intrahepatic cholangiocarcinoma (ICC) in young patients.
Methods: A retrospective analysis was performed in ICC patients referred to the Eastern Hepatobiliary Surgery Hospital in Shanghai, China. Among 317 consecutively enrolled patients, 40 patients were aged
Results: Group I had distinct features compared with group II, including a low frequency of hepatolithiasis (P = 0.000); a high positive rate of serum hepatitis B surface antigen (P = 0.000) and hepatitis B virus (HBV)-associated cirrhosis (P = 0.038); a high frequency of alpha-fetoprotein (> 400 microg/L) (P = 0.011); a low frequency of carbohydrate antigen 19-9 (> 37 U/mL) (P = 0.017); and a high frequency of liver histological inflammation (P = 0.002). Although there was no significant difference between the two groups in regards to hepatic schistosomiasis, alcohol-associated cirrhosis and cirrhosis due to other causes (P > 0.05), they only occurred in the elderly group.
Conclusion: The risk factors are significantly different between young and elderly ICC patients. HBV and HBV-associated cirrhosis are the most important risk factors for young ICC patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825336 | PMC |
| http://dx.doi.org/10.3748/wjg.v16.i7.881 | DOI Listing |
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