AI Article Synopsis
- Recent research indicates that the release of lysosomal enzymes, like beta-Glucuronidase, by certain white blood cells in the gums plays a significant role in tissue damage related to periodontal disease.
- A study involving 75 subjects divided into three groups aimed to analyze the correlation between beta-Glucuronidase levels in gingival crevicular fluid (GCF) and periodontal health in diabetic versus non-diabetic patients with chronic periodontitis.
- Findings revealed that patients with periodontitis had higher beta-Glucuronidase levels compared to controls, with diabetic patients experiencing more severe periodontal damage, suggesting a greater risk for worsening periodontal disease among diabetics.
Article Abstract
Recent evidences prove that, release of potent lysosomal enzymes e.g. beta-Glucuronidase by degranulation of polymorponuclear leukocytes in host gingiva may contribute significantly to tissue destruction and the pathogenesis of periodontal disease. The purpose of the present study was to compare and correlate GCF beta-Glucuronidase with periodontal status among diabetic and non-diabetic patients with chronic periodontitis. A total number of 75 patients were equally divided into Group I (control group), Group II (non diabetic with chronic periodontitis) and Group III (diabetic with chronic periodontitis). Clinical parameters like Plaque index, Gingival index, Probing Pocket Depth and RBS were recorded. The beta-Glucuronidase level in GCF of all three groups was determined by spectrophotometric analysis. It was observed that the periodontitis patients irrespective of their diabetic status, showed increased periodontal destruction with elevated level of beta-Glucuronidase than the controls. Also, the diabetic patients showed increased severity of periodontal destruction and the elevated level of beta-Glucuronidase, thus indicating diabetics at a higher risk for progressive periodontal destruction.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813552 | PMC |
| http://dx.doi.org/10.4103/0972-124X.44092 | DOI Listing |
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