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Dexmedetomidine suppresses glucose-stimulated insulin secretion in pancreatic β-cells.
FEBS Open Bio
December 2024
Department of Cell Physiology, Institute of Biomedical Science, Kansai Medical University, Hirakata, Osaka, Japan.
Article Synopsis
- Proper glycemic control is important in critical care settings, as it can impact patient outcomes and is influenced by factors such as insulin secretion and glucose metabolism.
- Various perioperative drugs, particularly dexmedetomidine (DEX), are shown to suppress glucose-stimulated insulin secretion, but the mechanisms remain unclear.
- Research using pancreatic cell lines and primary cells indicates that DEX reduces insulin secretion without significantly altering other cellular processes, suggesting that it affects insulin signaling pathways and exocytosis mechanisms.
Rationale and strategies for improving glycaemic control in diabetic patients undergoing cardiac surgery: a narrative review.
J Thorac Dis
November 2024
Department of Cardiothoracic Surgery, Royal Papworth Hospital, Cambridge, UK.
Background And Objective: The global prevalence of diabetes mellitus has markedly risen in recent years. Consequently, there has been a rise in the number of patients with diabetes undergoing cardiac surgery. Despite the existence of national and international guidelines to improve surgical outcomes in patients with diabetes, perioperative diabetes management optimisation remains inadequate resulting in these patients experiencing increased rates of surgical morbidity and mortality.
View Article and Find Full Text PDFGlucose-Sensing ChREBP Protein in the Pathogenesis of Dia-betic Retinopathy.
bioRxiv
December 2024
Wake Forest University, School of Medicine, Department of Biochemistry.
Glucose-sensing ChREBP and MondoA are transcriptional factors involved in lipogenic, inflammatory, and insulin signaling pathways implicated in metabolic disorders; however, limited ocular studies have been conducted on these proteins. We aimed to investigate the potential role of ChREBP in pathogenesis of diabetic retinopathy (DR). We used diabetic human and mouse retinal cryosections analyzed by immunohistochemistry.
View Article and Find Full Text PDFUse of automated insulin delivery during major surgery in patients with type 1 diabetes: Two case reports.
J Diabetes Investig
December 2024
Department of Anesthesiology and Intensive Therapy, Maria Sklodowska-Curie National Research Institute of Oncology Gliwice Branch, Gliwice, Poland.
With the rapid advancement of diabetes technology, the number of patients with type 1 diabetes (T1D) using automated insulin delivery (AID) systems is increasing, making the presence of such patients in the perioperative period more common. This study presents two cases of T1D patients who underwent thyroidectomy while using AID, following a protocol designed in collaboration with the diabetology, anesthesiology, and surgical teams. Two female patients, aged 12 and 33 years, both using AID systems, were admitted for elective thyroidectomy.
View Article and Find Full Text PDFMiddle segment preserving pancreatectomy versus total pancreatectomy: a comparative analysis of short- and long-term outcomes.
Surg Today
December 2024
Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Purpose: Middle-segment preserving pancreatectomy (MSPP) serves as an alternative to total pancreatectomy (TP) for preserving the pancreatic body in multifocal pancreatic neoplasms. Despite the potential benefits of TP, the detailed short- and long-term prognoses remain unclear. We evaluated the feasibility of MSPP by comparing the perioperative outcomes and postoperative endocrine and exocrine functions with those of TP.
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