AI Article Synopsis
- In the experimental allergic encephalomyelitis (EAE) model, there is an overactivation of a type of enzyme called calpains, specifically m-calpains.
- This hyperactivation is linked to the death of neurons and glial cells during the progression of EAE.
- Researchers suggest that m-calpaines may play a significant role in initiating this cell death process in EAE.
Article Abstract
In simulation of experimental allergic encephalomyelitis (EAE), a hyperactivation of calpaines occurs due to m-calpaines. The m-calpaines involvement in the process of initiation of neurons and glial cells death in the EAE development was suggested.
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