Objective: To evaluate the effects of magnetic attachment keepers on MRI images.
Methods: In in vitro part, keepers of MAGFIT EX 400, MAGFIT EX 600 and MAGNEDISC 800 magnetic attachment systems were cast into standard root-caps with different alloy respectively, including nickel-chromium alloy and gold-palladium alloy, or not be cast for contrast. In in vivo part, volunteers with keepers in different position and amount were included. All the specimens and volunteers were imaged by a Siemens SONATA 1.5-T MRI scanner. Extent of the artifacts in every slice was measured. The magnitude of the artifacts and the distortion of the anatomic structures were compared.
Results: All kinds of keepers being studied produced obvious MRI artifacts. The extent of MRI artifacts induced by MAGFIT EX 400 keepers, MAGFIT EX 600 keepers and MAGNEDISC 800 keepers are 158.94 mm, 168.52 mm and 173.00 mm, respectively. The images of mental region, tongue, palate, jawbone and sinus were evidently obscured by artifacts in all cases. When keeper was put in the molar region, the keeper-related MRI artifact may obscure the imaging of brain, spinal cord. SE sequence with right-left frequency-encoding direction was more desirable in MRI for the patients with magnetic attachment keepers.
Conclusion: Keepers of magnetic attachment system did induce obvious artifacts in MRI examination.
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Angew Chem Int Ed Engl
January 2025
Jinan University, State Key Laboratory of Bioactive Molecules and Druggability Assessment, CHINA.
Secupyritines A‒C are unique polycyclic Securinega alkaloids isolated from medicinal plant Flueggea suffruticosa. They feature a distinctive 6/6/6/5/6 fused pentacyclic ring system with a highly strained 2-oxa-6-aza[4.4.
View Article and Find Full Text PDFCell Chem Biol
December 2024
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:
Chemical inducers of proximity (CIPs) are molecules that recruit one protein to another and introduce new functionalities toward modulating protein states and activities. While CIP-mediated recruitment of E3 ligases is widely exploited for the development of degraders, other therapeutic modalities remain underexplored. We describe a non-degrader CIP-DNA-encoded library (CIP-DEL) that recruits FKBP12 to target proteins using non-traditional acyclic structures, with an emphasis on introducing stereochemically diverse and rigid connectors to attach the combinatorial library.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Pittsburgh, Pittsburgh, PA, USA.
Background: Employing a custom 60-channel single-transmit/32-channel receive Tic-Tac-Toe (TTT) coil in 7T MRI imaging has enhanced the resolution and contrast for identifying White Matter Hyperintensities (WMHs), which are critical markers in Alzheimer's disease and related dementias (AD/ADRD).
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J Indian Prosthodont Soc
January 2025
Department of Prosthodontics, K M Shah Dental College and Hospital, Sumandeep Vidyapeeth, Vadodara, Gujarat, India.
Aim: The aim is to evaluate and compare stress distribution characteristics of ball, magnet, and positioned attachment systems in single and double implant-retained overdentures using the finite element method (FEM).
Setting And Design: In vitro (in silico study) finite element analysis (FEA).
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Purpose: Using a thin semitendinosus tendon as an autograft is a risk factor for poor clinical outcomes after anterior cruciate ligament reconstruction. Preoperative evaluation of the cross-sectional area of the semitendinosus tendon using magnetic resonance imaging is useful. However, studies comparing the cross-sectional area of the semitendinosus tendon on magnetic resonance imaging and the collagen fibril diameter of the semitendinosus tendon are lacking.
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