To assess the importance of brain cytochrome P450 (P450) activity in mu opioid analgesic action, we generated a mutant mouse with brain neuron-specific reductions in P450 activity; these mice showed highly attenuated morphine antinociception compared with controls. Pharmacological inhibition of brain P450 arachidonate epoxygenases also blocked morphine antinociception in mice and rats. Our findings indicate that a neuronal P450 epoxygenase mediates the pain-relieving properties of morphine.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828325 | PMC |
| http://dx.doi.org/10.1038/nn.2497 | DOI Listing |
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