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To present the management and outcomes of a case of acute submacular hemorrhage due to neovascular age-related macular degeneration (nAMD). A single case was retrospectively evaluated. A 79-year-old man with a history of submacular hemorrhage from nAMD and persistent disease activity in the left eye presented with acute submacular hemorrhage in his better-seeing right eye, which was previously closely monitored for an extrafoveal serous pigment epithelial detachment without exudation.

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Submacular hemorrhage: My personal journey to the goal.

Graefes Arch Clin Exp Ophthalmol

October 2024

Department of Ophthalmology, Shiga University of Medical Science, Otsu, Japan.

Acute submacular hemorrhage (SMH) can be caused by various diseases including age-related macular degeneration (AMD), polypoidal choroidal vasculopathy (PCV), and retinal arterial microaneurysm (RAM). The natural course of submacular hemorrhage is generally poor. Animal studies have suggested that the removal of subretinal hemorrhage may effectively reduce retinal damage caused by hemorrhage in humans and removal of submacular hemorrhage have been performed with limited visual outcomes.

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Branch retinal vein occlusion (BRVO) is a common retinal vascular disorder typically characterized by distinct findings on fundus examination and optical coherence tomography (OCT). An unusual and challenging presentation involves a full-thickness macular hemorrhage extending from the internal limiting membrane (ILM) to the subretinal space. Here, we present the case of a 52-year-old male with type 2 diabetes mellitus who experienced sudden vision loss in the right eye and progressive vision decline in the left eye.

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Article Synopsis
  • Submacular hemorrhage (SMH) is a medical emergency that requires quick action to remove blood from beneath the fovea and address its cause, as damage to photoreceptors can start right after SMH occurs.* -
  • Clinicians consider multiple factors for SMH treatment, with the duration of visual symptoms often being the top priority, while imaging characteristics receive less focus despite their importance.* -
  • There is a call for a simplified treatment algorithm for SMH that emphasizes retinal imaging characteristics, aiming for consistent and effective treatment outcomes.*
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Article Synopsis
  • * Nineteen patients (13 males, 6 females) aged 14 to 85 were studied, with neovascular age-related macular degeneration being the most common cause; 68% had successful treatment outcomes linked to specific FAF imaging patterns.
  • * The research found that hypoautofluorescence on FAF was a strong predictor of successful resolution of SMH, indicating its potential value in guiding treatment decisions alongside other imaging methods.
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