AI Article Synopsis
- Chloroquine resistance in Plasmodium falciparum significantly affects global malaria control efforts.
- A study assessed the mRNA expression of 10 antioxidant defense genes in both chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) parasite clones after a short exposure to chloroquine.
- Results showed that the CQ-sensitive 3D7 clone had a stronger transcriptional response by overexpressing six genes compared to the three genes in the CQ-resistant Dd2 clone, indicating differing adaptive responses to chloroquine-induced oxidative stress.
Article Abstract
Resistance to chloroquine (CQ) in Plasmodium falciparum has a major impact on malaria control worldwide. To gain insight into early parasite stress response, mRNA expression profiles were determined for a set of 10 antioxidant defence genes in synchronized CQ-sensitive (3D7) and CQ-resistant (Dd2) clones under transient IC50 CQ-exposure (Dd2, 200 nM; 3D7, 14 nM). Upon 2-h CQ challenge, the mRNA upregulation detected was greater in 3D7 (six genes overexpressed at 1/3 of the intraerythrocytic cycle) than in Dd2 clone (three genes responding), providing evidence of an early transcriptional response to CQ-induced oxidative stress which might underlie some of the parasite's metabolic adaptation to the drug.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.actatropica.2010.01.013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!