[Effects of preemptive analgesia with flurbiprofen on the blood sugar and interleukin-6 of patients after radical excision of breast cancer].

Objective: To investigate the effects of preemptive analgesia with flurbiprofen on the blood sugar and Interleukin-6 of patients after radical excision of breast cancer.

Methods: A total of 60 ASA I-II patients scheduled for radical excision of breast cancer were randomly assigned to three groups: group A, B and C (n = 20 each), patients of group A and C received intravenous flurbiprofen 100 mg before or at the end of surgery respectively. Blood samples were collected from the patients before anaesthesia induction and 1, 6, 24 h after surgery for the determination of blood sugar and serum interleukin-6 concentration. Analgesic efficacy was assessed after surgery based on visual analog scales (VAS).

Results: The blood sugar and serum interleukin-6 concentration of the patients in three groups at different time points after surgery were significantly higher than those before surgery, and increased gradually in group B, and there were very significant difference between the time point of 1 h and 24 h after surgery (P < 0.01), but there were no increasing trend for those of group A and C. The blood sugar and serum interleukin-6 concentration of the patient of group A were significantly lower than those of group B and C (P < 0.01 or 0.05). The highest VAS of group A and C at different time points after surgery were significantly lower than that of group B(P < 0.05).

Conclusion: Preemptive analgesia with flurbiprofen 100 mg can effectively suppress the elevation of blood sugar and serum interleukin-6 concentration after radical excision of breast cancer, and is better than postoperation analgesia.