AI Article Synopsis
- The study aimed to determine how common Helicobacter pylori (Hp) infection is among children and teenagers aged 3 to 18 in Wuwei city, Gansu province, revealing a high prevalence of 72.3% among 938 subjects surveyed.
- Risk factors linked to Hp infection included dwelling type, parents' jobs, water source, kindergarten attendance, eating raw vegetables, poor oral hygiene, and breastfeeding, with drinking water source and kindergarten attendance being the most significant.
- The analysis indicated that maternal-child and sibling-sibling transmission are the main routes for Hp spread, and serological results showed that most infections in the region were type I Hp.
Article Abstract
Objective: To investigate the prevalence of Helicobacter pylori (Hp) infection among children aged 3 to 18 years old of Wuwei city, Gansu province.
Methods: The study was based upon a personal questionnaire and a determination of Hp antigen using the Hp stool antigen test (HpSA) method. A total of 938 subjects and 96 families were selected in Wuwei city. Eighty children and teenagers with a definite positive Hp stool antigen test were examined by serum Western blotting method.
Results: The prevalence of Hp was 72.3% (678/938) with no age difference. Prevalence of Hp infection was correlated with type of dwelling, occupation of parents, drinking water source, kindergarten attendance, consumption of raw vegetables, a poor oral hygiene and breast feeding etc. According to the multivariate analysis, drinking water source, kindergarten attendance and consumption of raw vegetables were most strongly associated with prevalence of Hp in children and adolescents. The infection rate of parents whose children were infected with Hp was higher than that of those whose children were not infected [82.3% (121/147) vs 47.4% (18/38), chi(2) = 19.736, P < 0.05]. The antibody responses of 57 samples (71.3%) from 80 children were of type I Hp and 23 samples (28.7%) type II.
Conclusions: Hp infective rate is high in Wuwei city. The data support maternal-child and sibling-sibling transmission as the primary transmission routes of Hp. The results of serological analysis confirm that the majority of Wuwei Hp infection is of type I.
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Article Synopsis
- * A study of 1,074 participants over age 50 in Wuwei City found that 1.4% tested positive for the disease, with a majority showing no symptoms.
- * Raising lambs was identified as a significant risk factor for brucellosis, emphasizing the need for improved surveillance and health education in these at-risk communities.
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