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The multidisciplinary management of HER2-positive breast cancer brain metastases: from new biological insights to future therapeutic options.
Front Oncol
December 2024
Department of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples, Italy.
The advent and success of new drugs for treating HER2-positive metastatic breast cancer has led to a constant improvement in disease and progression-free survival as well as overall survival. Despite these advantages, the overall survival and quality of life of patients with HER2-positive breast cancer brain metastases are significantly worse than the ones of patients with HER2-positive breast cancer metastases outside the brain. For this reason, prevention and treatment of brain metastasis remain a major clinical challenge and the keys to further improving the clinical and survival outcomes of HER2-positive breast cancer patients.
View Article and Find Full Text PDFReturn-to-School Experiences of Adolescents After Allogeneic Hematopoietic Cell Transplant: A Qualitative Interview Study of Transplant Recipients.
Pediatr Blood Cancer
December 2024
Division of Hematology/Oncology and Stem Cell Transplantation, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.
Background: Returning to school after allogeneic hematopoietic cell transplant (HCT) can improve quality of life and promote positive adjustment. However, this process may be challenging, and there is a limited understanding of school-aged children and adolescents' perspectives on this process.
Methods: We conducted semi-structured interviews over video with pediatric recipients of HCT (10-18 years of age at HCT; 1-7 years post HCT) who were treated at our institution and had returned to in-person school post HCT.
MoMA: Momentum contrastive learning with multi-head attention-based knowledge distillation for histopathology image analysis.
Med Image Anal
December 2024
School of Electrical Engineering, Korea University, Seoul, Republic of Korea. Electronic address:
There is no doubt that advanced artificial intelligence models and high quality data are the keys to success in developing computational pathology tools. Although the overall volume of pathology data keeps increasing, a lack of quality data is a common issue when it comes to a specific task due to several reasons including privacy and ethical issues with patient data. In this work, we propose to exploit knowledge distillation, i.
View Article and Find Full Text PDFMSR-UNet: enhancing multi-scale and long-range dependencies in medical image segmentation.
PeerJ Comput Sci
December 2024
Huaibei People's Hospital, Huaibei, China.
Transformer-based technology has attracted widespread attention in medical image segmentation. Due to the diversity of organs, effective modelling of multi-scale information and establishing long-range dependencies between pixels are crucial for successful medical image segmentation. However, most studies rely on a fixed single-scale window for modeling, which ignores the potential impact of window size on performance.
View Article and Find Full Text PDFExploring ChatGPT in clinical inquiry: a scoping review of characteristics, applications, challenges, and evaluation.
Ann Med Surg (Lond)
December 2024
School of Public Health Sciences, University of Waterloo, Waterloo, Ontario, Canada.
Introduction: Recent advancements in generative AI, exemplified by ChatGPT, hold promise for healthcare applications such as decision-making support, education, and patient engagement. However, rigorous evaluation is crucial to ensure reliability and safety in clinical contexts. This scoping review explores ChatGPT's role in clinical inquiry, focusing on its characteristics, applications, challenges, and evaluation.
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