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Structural Color Contact Lenses from Cholesteric Cellulose Liquid Crystals.
Small Methods
December 2024
Institute of Translational Medicine, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Colored contact lenses have gained popularity among young individuals owing to their ability to alter the appearance of the wearer's eyes. However, conventional lenses containing chemical dyes are susceptible to detachment of the pigment layer, which can lead to corneal damage. In this research, a novel cellulose-based structural color contact lens (SCCL) is presented that enhances aesthetic appeal via a cholesteric liquid crystal (CLC) layer.
View Article and Find Full Text PDFHow crosstalk between mitochondria, lysosomes, and other organelles can prevent or promote dry age-related macular degeneration.
Exp Eye Res
December 2024
Departments of Biochemistry and Ophthalmology, University of Washington, Seattle, WA, USA. Electronic address:
Organelles such as mitochondria, lysosomes, peroxisomes, and the endoplasmic reticulum form highly dynamic cellular networks and exchange information through sites of physical contact. While each organelle performs unique functions, this inter-organelle crosstalk helps maintain cell homeostasis. Age-related macular degeneration (AMD) is a devastating blinding disease strongly associated with mitochondrial dysfunction, oxidative stress, and decreased clearance of cellular debris in the retinal pigment epithelium (RPE).
View Article and Find Full Text PDFBiocompatibility of light responsive materials prepared for accommodative intraocular lenses manufacturing.
Int J Ophthalmol
December 2024
Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Aim: To investigate the biocompatibility and bacterial adhesion properties of light responsive materials (LRM) and analyze the feasibility and biosafety of employing LRM in the preparation of accommodative intraocular lenses (AIOLs).
Methods: Employing fundamental experimental research techniques, LRM with human lens epithelial cells (hLECs) and human retinal pigment epithelium cells (ARPE-19 cells) were co-cultured. Commercially available intraocular lenses (IOLs) were used as controls to perform cell counting kit-8 (CCK-8), cell staining under varying light intensities, cell adhesion and bacterial adhesion experiments.
Integrating Remote Photoplethysmography and Machine Learning on Multimodal Dataset for Noninvasive Heart Rate Monitoring.
Sensors (Basel)
November 2024
Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok 16424, Indonesia.
Non-contact heart monitoring is crucial in advancing telemedicine, fitness tracking, and mass screening. Remote photoplethysmography (rPPG) is a non-contact technique to obtain information about heart pulse by analyzing the changes in the light intensity reflected or absorbed by the skin during the blood circulation cycle. However, this technique is sensitive to environmental lightning and different skin pigmentation, resulting in unreliable results.
View Article and Find Full Text PDFAn In Vitro Strategy to Evaluate Ketoprofen Phototoxicity at the Molecular and Cellular Levels.
Int J Mol Sci
November 2024
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055 Katowice, Poland.
Article Synopsis
- Phototoxicity, a common issue linked to many medications including over-the-counter ones, highlights the importance of testing drugs for their potential to cause harm under UV light!
- This study focuses on the effects of ketoprofen on human skin cells, using various tests to analyze its cytotoxicity and phototoxicity under different treatment conditions!
- Findings revealed that ketoprofen poses the highest risk of phototoxic reactions when it is directly applied to cells during UV exposure, affecting both pigmented and non-pigmented skin cells!
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