AI Article Synopsis
- The study examined how type-4 resistant starch (RS) affects immune activity in mesenteric lymph nodes (MLNs) using rats.
- Rats fed an RS diet showed higher levels of serum immunoglobulin A and an increased CD4(+) T cell population compared to those on a cellulose diet.
- Results suggest that type-4 RS may help reduce allergic inflammation by promoting a greater presence of CD4(+) T cells and enhancing lymphocyte differentiation in the MLNs.
Article Abstract
We evaluated the immunomodulatory activity of type-4 resistant starch (RS) in mesenteric lymph nodes (MLNs) using a rat model. Sixteen male Sprague-Dawley rats were fed either a cellulose diet or an RS diet (RSD) for 4 weeks. Serum immunoglobulin A levels, as well as the CD4(+) T cell population and the ratio of CD4(+)/CD8(+) T cells in the MLNs of rats, were significantly elevated by replacing cellulose with RS in the diet. The survival rate of concanavalin A (Con A)-stimulated MLN lymphocytes and interleukin-4 secretion from the Con A-stimulated MLN lymphocytes were significantly increased in rats fed RSD. These results indicate that type-4 RS might ameliorate allergic inflammation in the MLNs of rats through an increased CD4(+) T cell population and enhanced differentiation of MLN lymphocytes into type-2 T cells.
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| http://dx.doi.org/10.1089/jmf.2009.1170 | DOI Listing |
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