AI Article Synopsis
- This study aimed to assess how well bevacizumab (Avastin) reduces corneal neovascularization in mice and compares different injection methods (intraocular vs. subconjunctival).
- Neovascularization was induced in 125 mice, who then received bevacizumab via different injection routes, with results measured through digital imaging, immunohistochemistry, and VEGF level analysis.
- Results showed that bevacizumab treatment reduced neovascularization, with intraocular injections being the most effective, while subconjunctival injections had the fastest initial response.
Article Abstract
Purpose: This study sought to evaluate the efficacy of bevacizumab (Avastin), an anti-VEGF agent, in the reduction of corneal neovascularization in a rodent model, and compare between the effect of intraocular and subconjunctival injection.
Methods: Corneal neovascularization was induced by application of a mixture of 75% silver nitrate and 25% potassium nitrate to the corneal center of the right eye of 125 mice. Immediately thereafter, 75 eyes were treated with subconjunctival, anterior chamber, or intravitreal injection of bevacizumab. The remaining mice served as a control. The groups were compared at different postoperative time points for percentage area of neovascularization evaluated by digital photos, the presence of corneal stromal vascular endothelial cells studied by immunohistochemical staining, and VEGF levels measured by real-time PCR.
Results: In the untreated eyes, percentage area of neovascularization increased from 11.3 +/- 7% on day 2 to 20 +/- 8.9% on day 4, 47 +/- 25.4% on day 8, and 51 +/- 24.7% on day 10. The percentage area of neovascularization following subconjunctival injection was 7 +/- 2.9% on day 2, 15.7 +/- 6% on day 4, 32.2 +/- 15.2% on day 8, and 39.7 +/- 14.5% on day 10. The percentage area of neovascularization following anterior chamber injection was 14.4 +/- 3% on day 2, 16.5 +/- 6.3% on day 4, 26.3 +/- 6.5% on day 8, and 19.8 +/- 1.2% on day 10. The percentage area of neovascularization following intravitreal injection was 11 +/- 2.5% on day 2, 14.7 +/- 5% on day 4, 23.5 +/- 6.5% on day 8, and 24.2 +/- 14.9% on day 10.
Conclusions: Bevacizumab injections partially inhibit the growth of corneal neovascularization induced by acute chemical injury in a mouse model. The intraocular routes of injection were found to be the most effective, and the subconjunctival route of injection yielded the earliest peak response.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/02713680903429007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Relationship Between Dietary Patterns and Blood Pressure During Adolescence: A Longitudinal Analysis From Dados Study.
Am J Hum Biol
January 2025
LIFE Research Group, University Jaume I, Castellon, Spain.
Background: Previous research in adults has suggested that healthy dietary patterns could be an effective strategy for blood pressure (BP) control. However, during adolescence, the scientific literature examining this relationship is scarce and controversial since inverse and null associations have been reported. Thus, the aim of our study was to analyze the relationship between the level of adherence to the Mediterranean diet (MD) and consumption of fresh fruits and vegetables at baseline with changes in BP over a two-year period during adolescence.
View Article and Find Full Text PDFCascade of care for people with positive symptoms of common cancers in selected primary health centres of Puducherry: An explanatory mixed-method study.
Indian J Med Res
November 2024
Department of Radiodiagnosis, Jawaharlal Institute of Postgraduation Medical Education and Research, Puducherry, India.
Background & objectives Cancer is a leading cause of death worldwide and constitutes a public health priority. Delays in diagnosis and treatment of cancer can adversely impact survival, recovery, and cost of treatment. The objective of this study was to estimate the proportion seeking timely care among those having early warning signals for oral, breast or cervical cancer and to explore the facilitators and barriers to early detection.
View Article and Find Full Text PDFTrends in dengue virus positivity & serotyping in Rajasthan.
Indian J Med Res
November 2024
Department of Health Research, Indian Council of Medical Research, New Delhi, India.
Background & objectives Dengue virus causes frequent outbreaks and epidemics with high morbidity and mortality. It is important to monitor the trends of the dengue virus and its serotypes. We carried out the present work to study the prevalence of the dengue virus and its serotypes in clinically suspected cases of dengue in Rajasthan.
View Article and Find Full Text PDFA study on anxiety and depression symptoms among menopausal women: a web based cross sectional survey.
Front Public Health
December 2024
Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
Background: An essential part of aging is menopause, which indicates the final phase of the female reproductive cycle. The objective of this research was to assess anxiety and depressive symptoms among menopausal women in Asir region, Saudi Arabia.
Methods: The cross-sectional survey was carried out in February to June 2024, using a random sampling procedure, study participants were selected.
Fatal outcome related to drug reaction with eosinophilia and systemic symptoms: a disproportionality analysis of FAERS database and a systematic review of cases.
Front Immunol
December 2024
Department of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background: Drug rash with eosinophilia and systemic symptoms (DRESS) is a life-threatening severe cutaneous adverse reaction.
Objective: This study aims to study fatal DRESS cases using FAERS database and systematic review.
Methods: Data of the FDA Adverse Event Reporting System (FAERS) database were extracted and manipulated.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!