[Dysfunction of vascular endothelium in patients with coronary heart disease].

Patients with FC II-IV CHD and angina of effort were divided into 3 groups (compensated, subcompensated, and decompensated types) based on vascular reaction to local ischemic load Serum lipid spectrum, parameters of hemostasis and blood flow were evaluated before and after the load. It was shown that each type of vascular reaction had specific predictors. Vasodilation in "compensated" patients was largely due to hydrodynamic changes in the vascular bed. The "subcompensated" type was characterized by reduced sensitivity to this changes "decompensated" type of reactivity was related to metabolic rather than hydrodynamic disorders accounting for paradoxic vasoconstriction in response to ischemic load.