Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
A 52-year-old man underwent abdominoperineal resection of the rectum, a partial hepatectomy, and intrahepatic arterial infusion chemotherapy for rectal cancer and liver metastases in 2001. Due to recurrent liver metastases, additional hepatectomies were performed in 2003 and 2005. He then underwent radiofrequency ablation therapy and systemic chemotherapies with mFOLFOX6 and FOLFORI. In July 2007, positron emission tomography (PET) and computed tomography (CT) revealed a high level of (18)F-fluorodeoxyglucose (FDG) accumulation in the liver. After 6 cycles of chemotherapy with bevacizumab plus mFOLFOX6, the FDG accumulation disappeared. The multidisciplinary therapy was effective, yielding long term survival of over 8 years.
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