AI Article Synopsis
- The report highlights specific substructural features that can help identify promiscuous compounds that show up frequently in biochemical high throughput screens.
- These compounds are often overlooked by standard filters meant to detect reactive compounds, making them harder to identify.
- Despite being analyzed through a single assay detection method, these compounds are frequently cited in various studies as promising candidates for further research.
Article Abstract
This report describes a number of substructural features which can help to identify compounds that appear as frequent hitters (promiscuous compounds) in many biochemical high throughput screens. The compounds identified by such substructural features are not recognized by filters commonly used to identify reactive compounds. Even though these substructural features were identified using only one assay detection technology, such compounds have been reported to be active from many different assays. In fact, these compounds are increasingly prevalent in the literature as potential starting points for further exploration, whereas they may not be.
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| http://dx.doi.org/10.1021/jm901137j | DOI Listing |
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