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Effectiveness of Buspirone in Alleviating Anxiety Symptoms in Patients with Depressive Disorder: A Multicenter Prospective Observational Study in Korea.
Clin Psychopharmacol Neurosci
February 2025
Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Objective: We aimed to investigate the effectiveness of buspirone as an adjunctive therapy for alleviating anxiety symptoms in patients with depressive disorders who are already taking antidepressants.
Methods: This was an open-label prospective multicenter non-interventional observational study conducted over 12 weeks. We enrolled 180 patients diagnosed with depressive disorders according to DSM-5 criteria and Hamilton Anxiety Rating Scale (HAMA) scores ≥ 18.
Enabling systemic identification and functionality profiling for Cdc42 homeostatic modulators.
Commun Chem
November 2024
Department of Chemistry and Biochemistry, College of Arts and Sciences, University of South Carolina, Columbia, SC, USA.
Maintaining body homeostasis is the ultimate key to health. There are rich resources of bioactive materials for the functionality of homeostatic modulators (HMs) from both natural and synthetic chemical repertories. HMs are powerful modern therapeutics for human diseases including neuropsychiatric diseases, mental disorders, and drug addiction (e.
View Article and Find Full Text PDFANXIOLYTICS: Introduction to a special issue celebrating 50 years of Pharmacology, Biochemistry and Behavior.
Pharmacol Biochem Behav
December 2024
Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. Electronic address:
Association between psychopharmacotherapy and postpartum hemorrhage.
AJOG Glob Rep
November 2024
Northwell, New Hyde Park, NY (Jackson, Kouba, Meirowitz, Keller, Bracero, and Blitz).
Background: Prior studies evaluating the relationship between psychopharmacotherapy (PPT), and postpartum hemorrhage (PPH) have yielded inconsistent findings. Clarifying this potential relationship is important for effective counseling and risk stratification.
Objectives: Our primary objective was to evaluate the association between prenatal exposure to PPT (any drug class) and the occurrence of PPH requiring transfusion of packed red blood cells (PPH+pRBC) after systematically adjusting for known hemorrhage risk factors at the time of admission for delivery.
A Proposed Algorithm for the Pharmacological Treatment of Generalized Anxiety Disorder in the Older Patient.
J Geriatr Psychiatry Neurol
October 2024
Psychiatry Department, VA Boston Healthcare System, Brockton, MA, USA.
Article Synopsis
- A new algorithm from Harvard focuses on treating generalized anxiety disorder (GAD) specifically in older adults, reviewing relevant studies to determine medication effectiveness.
- Selective serotonin reuptake inhibitors (SSRIs), especially sertraline and escitalopram, are recommended as the first-line treatments, with alternatives like buspirone suggested for minimizing sexual side effects.
- If initial treatments don’t work, other options include different SSRIs, SNRIs, and medications like pregabalin or gabapentin, while caution is advised with benzodiazepines and hydroxyzine due to potential risks in elderly patients.
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