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Explainable Machine Learning to Predict Treatment Response in Advanced Non-Small Cell Lung Cancer.
JCO Clin Cancer Inform
January 2025
Emory University School of Medicine, Atlanta, GA.
Purpose: Immune checkpoint inhibitors (ICIs) have demonstrated promise in the treatment of various cancers. Single-drug ICI therapy (immuno-oncology [IO] monotherapy) that targets PD-L1 is the standard of care in patients with advanced non-small cell lung cancer (NSCLC) with PD-L1 expression ≥50%. We sought to find out if a machine learning (ML) algorithm can perform better as a predictive biomarker than PD-L1 alone.
View Article and Find Full Text PDFZero-Crosstalk Tumor-Targeting Ratiometric Near-Infrared γ-Glutamyltranspeptidase Probe for Fluorescent-Guided Surgical Resection of Orthotopic Hepatic Tumor.
Anal Chem
January 2025
Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, Hunan Provincial University Key Laboratory for Environmental and Ecological Health, College of Chemistry, Xiangtan University, Xiangtan 411105, P.R. China.
The challenge of "false positive" signals significantly complicates tumor localization and surgical resection, which are pivotal for successful tumor surgeries. Therefore, the development of a method for preoperative tumor localization and intraoperative margin determination holds considerable promise for improving surgical outcomes. In this study, a zero-crosstalk ratiometric tumor-targeting near-infrared (NIR) fluorescent probe was developed for precise cancer diagnosis and intraoperative navigation via NIR fluorescence imaging.
View Article and Find Full Text PDFPerovskite retinomorphic image sensor for embodied intelligent vision.
Sci Adv
January 2025
Department of Micro/Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Retinomorphic systems that can see, recognize, and respond to real-time environmental information will extend the complexity and range of tasks that an exoskeleton robot can perform to better assist physically disabled people. However, the lack of ultrasensitive, reconfigurable, and large-scale integratable retinomorphic devices and advanced edge-processing algorithms makes it difficult to realize retinomorphic hardware. Here, we report the retinomorphic hardware prototype with a 4096-pixel perovskite image sensor array as core module to endow embodied intelligent vision functionalities.
View Article and Find Full Text PDFIR-Driven Multisignal Conditioning for Multiplex Detection: Thermal-Responsive Triple DNA-Mediated Reconfigurable Photoelectrochemical/Photothermal Dual-Mode Strategy.
ACS Sens
January 2025
College of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, Changchun 130012, China.
Superior to traditional multiplex photoelectrochemical (PEC) sensors, integrated multitarget assay on a single reconstructive electrode interface is promising in real-time detection through eliminating the need of specialized instrumentation and cumbersome interfacial modifications. Current interface reconstruction approaches including pH modulation and bioenzyme cleavage involve biohazardous and time-consuming operations, which cannot meet the demand for rapid, eco-friendly, and portable detection, which are detrimental to the development of multiplex PEC sensors toward portability. Herein, we report a pioneer work on IR-driven "four-to-one" multisignal conditioning to facile reconfigure electrode interface for multitarget detection via photoelectrochemical/photothermal dual mode.
View Article and Find Full Text PDFTherapeutic potential of mesenchymal stem cells on cholesterol homeostasis-associated genes in AD-like rats.
FASEB J
January 2025
Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Cholesterol is vital for nerve processes. Changes in cholesterol homeostasis lead to neurodegeneration and Alzheimer's disease (AD). In recent years, extensive research has confirmed the influential role of adipose tissue mesenchymal stem cells (MSCs) in managing AD.
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