AI Article Synopsis
- Developed an induced circular dichroism (ICD) probe using a chromophore-linked alkynyldeoxyribose skeleton to study DNA duplex structures in visible light.
- Observed strong ICD signals in Z-form duplexes, formed at high NaCl concentrations, compared to faint signals in B-form duplexes at low NaCl concentrations.
- The probe's effectiveness in promoting the B to Z transition of oligonucleotides was linked to the chromophores being attached to the 5' ends of the strands.
Article Abstract
We have developed an induced circular dichroism (ICD) probe with a chromophore-linked alkynyldeoxyribose skeleton for analyzing higher-order structures of DNA duplexes in the visible-light region. When CG-repeated oligonucleotides (ODNs) with the probe at their 5' ends adopted Z-form duplexes at a high NaCl concentration, strong ICD signals were observed at the absorptive region of the chromophore. On the other hand, their B-form duplexes, formed at a low NaCl concentration, produced a faint ICD signal. The specific ICD for the Z-form duplexes was found to appear only when the chromophores were attached at the 5' ends of each of the ODNs. Furthermore, the chromophoric alkynylnucleoside residues effectively promoted the B to Z transition of the ODN.
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| http://dx.doi.org/10.1002/chem.200902882 | DOI Listing |
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