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APP antisense oligonucleotides are effective in rescuing mitochondrial phenotypes in human iPSC-derived trisomy 21 astrocytes.
Alzheimers Dement
January 2025
Department of Neuroscience, City University of Hong Kong, Hong Kong, Hong Kong.
Introduction: Antisense oligonucleotides (ASOs) have shown promise in reducing amyloid precursor protein (APP) levels in neurons, but their effects in astrocytes, key contributors to neurodegenerative diseases, remain unclear. This study evaluates the efficacy of APP ASOs in astrocytes derived from an individual with Down syndrome (DS), a population at high risk for Alzheimer's disease (AD).
Methods: Human induced pluripotent stem cells (hiPSCs) from a healthy individual and an individual with DS were differentiated into astrocytes.
Assessing Aberrant Subclavian Artery on High-Resolution Esophageal Manometry.
Gastro Hep Adv
October 2024
Division of Gastroenterology, Mayo Clinic, Jacksonville, Florida.
Amino acid assisted synthesis of CDs: a novel paradigm in plant tissue culture media for enhanced cellular effects and biotechnological advancements.
RSC Adv
January 2025
Centre for Nano Bio Polymer Science and Technology, Department of Physics, St. Thomas College Palai Kerala 686574 India +919446126926.
We report a green approach to prepare carbon dots (CDs) with fresh tomatoes as carbon sources and amino acids as dopants (ACDs) by a microwave assisted method. The synthesised CDs were analysed by UV-visible absorption spectroscopy, photoluminescence spectroscopy, high resolution transmission electron spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, X-ray photo electron spectroscopy. An MTT assay was used to evaluate the cytotoxicity of CDs toward L929 cells and found that CDs exhibit low cytotoxicity.
View Article and Find Full Text PDFReactivity of Wet scCO toward Reservoir and Caprock Formations under Elevated Pressure and Temperature Conditions: Implications for CCS and CO-Based Geothermal Energy Extraction.
Energy Fuels
January 2025
Geothermal Energy and Geofluids Group, Institute of Geophysics, Department of Earth and Planetary Sciences, ETH Zurich, Zurich 8092, Switzerland.
Carbon capture and storage (CCS) and CO-based geothermal energy are promising technologies for reducing CO emissions and mitigating climate change. Safe implementation of these technologies requires an understanding of how CO interacts with fluids and rocks at depth, particularly under elevated pressure and temperature. While CO-bearing aqueous solutions in geological reservoirs have been extensively studied, the chemical behavior of water-bearing supercritical CO remains largely overlooked by academics and practitioners alike.
View Article and Find Full Text PDFIntegrating attention mechanism and boundary detection for building segmentation from remote sensing images.
Front Neurorobot
January 2025
College of Artificial Intelligence, Taiyuan University of Technology, Jinzhong, Shanxi, China.
Accurate building segmentation has become critical in various fields such as urban management, urban planning, mapping, and navigation. With the increasing diversity in the number, size, and shape of buildings, convolutional neural networks have been used to segment and extract buildings from such images, resulting in increased efficiency and utilization of image features. We propose a building semantic segmentation method to improve the traditional Unet convolutional neural network by integrating attention mechanism and boundary detection.
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