AI Article Synopsis
- Phospholipase Cgamma1 (PLCgamma1) is crucial for T cell receptor signaling in T cells, influencing their development and function.
- Mice lacking PLCgamma1 in T cells show issues with positive and negative selection, reduced thymocytes, and impaired T cell activation and cytokine release.
- The absence of PLCgamma1 also negatively impacts the development of regulatory T cells, leading to inflammatory and autoimmune symptoms, highlighting its importance for T cell health and tolerance.
Article Abstract
Phospholipase Cgamma1 (PLCgamma1) is an important signaling effector of T cell receptor (TCR). To investigate the role of PLCgamma1 in T cell biology, we generated and examined mice with T cell-specific deletion of PLCgamma1. We demonstrate that PLCgamma1 deficiency affects positive and negative selection, significantly reduces single-positive thymocytes and peripheral T cells, and impairs TCR-induced proliferation and cytokine production, and the activation of ERK, JNK, AP-1, NFAT, and NF-kappaB. Importantly, PLCgamma1 deficiency impairs the development and function of FoxP3(+) regulatory T cells, causing inflammatory/autoimmune symptoms. Therefore, PLCgamma1 is essential for T cell development, activation, and tolerance.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822604 | PMC |
| http://dx.doi.org/10.1084/jem.20090880 | DOI Listing |
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