AI Article Synopsis
- The Cell Ontology (CL) is focused on creating a comprehensive representation of cell types from various biological contexts, both in live organisms and lab settings.
- Recent revisions have specifically enhanced the section of the CL related to hematopoietic cells, addressing issues like hierarchy and logical definitions, and integrating external ontologies such as the Protein Ontology and Gene Ontology.
- These updates not only improve the specific area of hematopoietic cells but also set a model for ongoing improvements across the entire Cell Ontology.
Article Abstract
The Cell Ontology (CL) aims for the representation of in vivo and in vitro cell types from all of biology. The CL is a candidate reference ontology of the OBO Foundry and requires extensive revision to bring it up to current standards for biomedical ontologies, both in its structure and its coverage of various subfields of biology. We have now addressed the specific content of one area of the CL, the section of the ontology dealing with hematopoietic cells. This section has been extensively revised to improve its content and eliminate multiple inheritance in the asserted hierarchy, and the groundwork has been laid for structuring the hematopoietic cell type terms as cross-products incorporating logical definitions built from relationships to external ontologies, such as the Protein Ontology and the Gene Ontology. The methods and improvements to the CL in this area represent a paradigm for improvement of the entire ontology over time.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892030 | PMC |
| http://dx.doi.org/10.1016/j.jbi.2010.01.006 | DOI Listing |
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