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Comment on "Celiac Axis Stenosis Is an Underestimated Risk Factor for Increased Morbidity After Pancreatoduodenectomy".
Ann Surg Open
December 2024
From the Department of Hepato-Biliary-Pancreatic Surgery, Kyorin University Hospital, Tokyo, Japan.
Modeling of heteroaggregation driven buoyant microplastic settling: Interaction with multiple clay particles.
Sci Total Environ
December 2024
Key Laboratory of Humid Sub-tropical Eco-geographical Process of Ministry of Education, Fujian Normal University, Fuzhou 350117, China; School of Geographical Sciences, School of Carbon Neutrality Future Technology, Fujian Normal University, Fuzhou 350117, China. Electronic address:
The ecological risk of microplastics (MPs) has received widespread attention, but understanding ecological risk starts with understanding environmental migration. Heteroaggregation is an important process that affects the vertical migration of MPs, and the mathematical model is a common tool used to project the migration behavior of MPs. However, the mathematical model based on the aggregation of MPs with one clay particle is not applicable to simulate the migration behavior of buoyant microplastic (BMP).
View Article and Find Full Text PDFConjugate Position of Glucuronide and Sulfate in Piceatannol Derivatives Affects the Stability and Hydrolytic Resistance of the Conjugate in Biological Matrices.
J Agric Food Chem
December 2024
Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu-shi, Toyama 939-0398, Japan.
Piceatannol, a stilbene compound, undergoes a comprehensive phase II metabolism mediated by UDP-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs) in humans. Despite their well-documented beneficial effects on health, their detailed pharmacokinetic fate, including the metabolite structure and properties, is poorly understood. Thus, we determined the structure of seven glucuronides and six sulfates transformed from piceatannol and its methylated derivatives in recombinant yeast cells expressing UGTs or SULTs.
View Article and Find Full Text PDFObstructive sleep apnea syndrome (OSAS) in women: A forgotten cardiovascular risk factor.
Maturitas
December 2024
Department of Translational and Precision Medicine, Sapienza-University of Rome, Viale del Policlinico 155, Rome 00161, Italy. Electronic address:
Sleep-disordered breathing is a highly prevalent disorder with negative impact on healthcare systems worldwide. This condition has detrimental effects on cardiovascular health and quality of life, and is frequently associated with a variety of comorbidities, including cardiovascular disease, heart failure, diabetes and atrial fibrillation. Nevertheless, it remains frequently undiagnosed and undertreated, especially in specific populations.
View Article and Find Full Text PDFAddressing treatment switching in the ALTA-1L trial with g-methods: exploring the impact of model specification.
BMC Med Res Methodol
December 2024
Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Faculty of Medicine, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
Article Synopsis
- Treatment switching in clinical trials complicates causal inference, making intention-to-treat (ITT) analyses less reliable for determining the true treatment effect.
- The ALTA-1L trial on brigatinib versus crizotinib highlighted this issue, showing more promising results for brigatinib when removed from treatment switching scenarios, via methods like Inverse Probability of Censoring Weights (IPCW).
- Re-analysis using IPCW and g-methods suggested that the treatment effect of brigatinib on overall survival may be significantly better than previously estimated, indicating that standard ITT analysis might underestimate treatment benefits.
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