AI Article Synopsis
- The study evaluated the effectiveness of an autoclaved cercarial vaccine (ACV) in protecting Swiss albino mice from Schistosoma mansoni infection by dividing them into a control group and several vaccinated groups.
- The vaccinated groups received different doses of the ACV, with the single 0.1 ml dose showing the best results in reducing infection levels.
- The findings indicated a significant decrease in adult worm numbers, liver and intestinal ova, and granuloma size, along with increased IL-10 mRNA expression in vaccinated mice compared to the control group.
Article Abstract
This study assessed the effectiveness of autoclaved cercarial vaccine (ACV) in protection against Schistosoma mansoni infection in 125 Swiss albino mice classified into two main groups: GI: a control group. GII: a test vaccinated with ACV, in a single dose of 0.1 ml of 10(4) ml ACV (G.IIa), double dose; 0.2ml (G.IIb) and two single doses 2 weeks apart (G.IIc). Four weeks later, all mice were challenged with S. mansoni cercariae and sacrificed 10 weeks post infection (P.I.). The results revealed that the vaccine in a single dose (G.IIa) induced a high level of protection against S. mansoni infection. There was a significant reduction in the mean number of adult worm (91.12%), ova/gram liver (91.87%), ova/gram intestine (89.09%) and number & size of granulomas in liver (92.92% & 43.53% respectively). Besides, ACV induced a significant increase in the level of IL-10 mRNA expression as compared to the control group.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!