Disappearance of carbon monoxide from the blood: Comparison of the one-exponential and two-exponential elimination models for rat.

Scand J Work Environ Health

Department of Epidemiology and Biometry, Institute of Occupational Health, Helsinki, Finland.

Published: September 1981

AI Article Synopsis

  • The study focused on how carbon monoxide is removed from rat blood when starting with a high concentration of carboxyhemoglobin (40%).
  • The researchers found that using a two-exponential model provided a more accurate fit for the data compared to a one-exponential model.
  • However, the differences in estimates of carbon monoxide levels between the two models were minimal, suggesting that the simpler one-exponential model is generally adequate for practical use.

Article Abstract

The elimination of carbon monoxide from rat blood was studied from a starting point of a nonsteady-state concentration of 40% for carboxyhemoglobin (COHb). The accuracy of the fit was statistically improved by the employment of a two-exponential elimination model rather than that of the one-exponential model. Yet, the differences in the COHb estimates attained with the two models were negligible. Therefore, for practical purposes, the one-exponential model seems reasonably reliable for estimating COHb.

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Source
http://dx.doi.org/10.5271/sjweh.3116DOI Listing

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