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Abnormal myocardial kinetics of 123I-heptadecanoic acid in subjects with impaired glucose tolerance.
Diabetologia
May 1997
Department of Clinical Nutrition, University of Kuopio, Finland.
Increased triglyceride accumulation has been observed in the diabetic heart, but it is not known whether the abnormalities in myocardial fatty acid metabolism differ between insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) diabetic patients or whether they are present even prior to overt diabetes. Therefore, we studied myocardial fatty acid kinetics with single-photon emission tomography using 123I-heptadecanoic acid (HDA) in four groups of men: impaired glucose tolerance (IGT) (n = 13, age 53 +/- 2 years, mean +/- SEM), IDDM (n = 8, age 43 +/- 3 years), NIDDM (n = 10, age 51 +/- 2 years) and control subjects (n = 8, age 45 +/- 4 years). Echocardiography and myocardial perfusion scintigraphy (IGT and NIDDM groups) were performed to study cardiac function and flow.
View Article and Find Full Text PDFDiagnosis of coronary artery disease using exercise echocardiography and positron emission tomography: comparison and analysis of discrepant results.
J Am Soc Echocardiogr
August 1992
Department of Cardiology, Cleveland Clinic Foundation, Ohio.
Both exercise echocardiography and rubidium-82 positron emission tomography are used in the detection and characterization of coronary artery disease. This study compared results of both in 74 patients with known coronary anatomy, by use of exercise echocardiography before and after treadmill exercise and positron emission tomography with intravenous dipyridamole-handgrip stress. Significant (greater than 50%) coronary stenoses were present in 70 patients; exercise echocardiography and positron emission tomography each identified 63 patients (sensitivity 90%).
View Article and Find Full Text PDFTwo-dimensional Doppler echocardiographic correlation of dipyridamole-thallium stress testing with isometric handgrip.
Am Heart J
May 1991
Department of Medicine, University of Massachussetts Medical Center, Worcester 01655.
To determine how frequently new wall-motion abnormalities that are indicative of ischemia accompany thallium redistribution, 47 consecutive patients underwent two-dimensional echocardiography during routine dipyridamole-thallium stress testing. A secondary aim of the study was to determine whether the addition of isometric handgrip exercises to the standard dipyridamole imaging protocol increased the frequency of wall-motion abnormalities or thallium redistribution. Echocardiograms and thallium scans were independently interpreted, and wall-motion abnormalities that appeared with dipyridamole, handgrip exercise, or both were compared with results of thallium imaging.
View Article and Find Full Text PDFThe aim of this study was to assess the possibility of increasing the sensitivity of dipyridamole-echocardiography testing (DET:2-D echo monitoring during dipyridamole infusion) by combining this procedure with handgrip testing. Dipyridamole-handgrip test (DHT) was therefore performed in 24 patients with rest/effort angina, negative DET, and negative handgrip-echo (without dipyridamole pretreatment). DHT consisted of 4.
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