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Swab Testing to Optimize Pneumonia treatment with empiric Vancomycin (STOP-Vanc): study protocol for a randomized controlled trial.
Trials
December 2024
Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Background: Vancomycin, an antibiotic with activity against methicillin-resistant Staphylococcus aureus (MRSA), is frequently included in empiric treatment for community-acquired pneumonia (CAP) despite the fact that MRSA is rarely implicated in CAP. Conducting polymerase chain reaction (PCR) testing on nasal swabs to identify the presence of MRSA colonization has been proposed as an antimicrobial stewardship intervention to reduce the use of vancomycin. Observational studies have shown reductions in vancomycin use after implementation of MRSA colonization testing, and this approach has been adopted by CAP guidelines.
View Article and Find Full Text PDFProbiotic and postbiotic interference exhibit anti-adhesion effects against clinical methicillin-resistant Staphylococcus aureus (MRSA) and impede MRSA-induced intestinal epithelial hyper-permeability in HT-29 cell line.
Microb Pathog
December 2024
Molecular Biology Unit, Dairy Microbiology Division, ICAR-National Dairy Research Institute, Karnal, 132001, Haryana, India; Dairy Bacteriology Section, Southern Regional Station, ICAR-National Dairy Research Institute, Adugodi, 560030, Bengaluru, Karnataka, India. Electronic address:
This study investigates the dynamics of MRSA de-colonization on HT-29 cell line using effective strategies like probiotics and postbiotics. Exploring novel alternatives to combat infections caused by antibiotic-resistant pathogens is an urgent need. Harnessing the antagonistic properties of live probiotics and their heat-killed preparations (postbiotics) to curb the growth of AMR pathogens represents a promising and essential area of contemporary research.
View Article and Find Full Text PDFCLINICAL EPIDEMIOLOGY OF NASAL COLONISATION WITH STAPHYLOCOCCUS AUREUS AMONG PAEDIATRIC INPATIENTS AT THE UNIVERSITY COLLEGE HOSPITAL, IBADAN, NIGERIA.
West Afr J Med
November 2024
Department of Paediatrics , University College Hospital, Ibadan.
Background: Colonisation precedes Staphylococcus aureus (S. aureus) infections with associated high morbidity and mortality, especially in hospitalised patients. S.
View Article and Find Full Text PDFInterventions targeting the nasal microbiome to eradicate methicillin-resistant Staphylococcusaureus.
Clin Microbiol Infect
October 2024
Infectious Diseases Section, Department of Medicine, Veterans Affairs Eastern Colorado Healthcare System, 1700 North Wheeling, Aurora, CO, USA; Infectious Diseases Division, Department of Medicine, University of Colorado Anschutz School of Medicine, Aurora, CO, USA. Electronic address:
Background: Staphylococcus aureus is an important pathogen in many sites, including the bloodstream, skin and soft tissue, bone and joints. When infection is caused by methicillin-resistant S. aureus (MRSA), therapy is more difficult and outcomes are less favourable.
View Article and Find Full Text PDFEuropean Society of Clinical Microbiology and Infectious Diseases/European Committee on infection control clinical guidelines on pre-operative decolonization and targeted prophylaxis in patients colonized by multidrug-resistant Gram-positive bacteria before surgery.
Clin Microbiol Infect
December 2024
Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, The Netherlands. Electronic address:
Scope: The aim of these guidelines is to provide recommendations for decolonization and perioperative antibiotic prophylaxis (PAP) in multidrug-resistant Gram-positive bacteria (MDR-GPB) adult carriers before inpatient surgery.
Methods: These European Society of Clinical Microbiology and Infectious Diseases/European Committee on Infection Control guidelines were developed following a systematic review of published studies targeting methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci, methicillin-resistant coagulase-negative Staphylococci, and pan-drug-resistant-GPB. Critical outcomes were the occurrence of surgical site infections (SSIs) caused by the colonizing MDR-GPB and SSIs-attributable mortality.
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