AI Article Synopsis
- The study investigated how D-sorbitol affects the gelling properties of methylcellulose in water.
- Adding 25-30% D-sorbitol to 1.0-2.0% methylcellulose lowered the gelation temperature significantly, making it range from around 53°C to between room temperature and 37°C, and also enhanced the gel's strength.
- The release of acetaminophen from the methylcellulose gels with D-sorbitol was determined to be diffusion-controlled.
Article Abstract
The aim of this study was to examine the effect of D-sorbitol on the gelation characteristics of methylcellulose in aqueous solution. The addition of D-sorbitol at concentrations of between 25 and 30% (w/v) to 1.0-2.0% (w/v) methylcellulose solutions reduced the gelation temperature from approximately 53 degrees Celsius to values between ambient and 37 degrees Celsius and increased the strength of the gel. The in vitro release of acetaminophen (paracetamol) from 2.0% (w/v) methylcellulose gels containing 20-30% (w/v) D-sorbitol gel was diffusion-controlled.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1248/cpb.58.247 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Data on hydrodynamic flow and aspiration mechanisms in a patient-specific pharyngolaryngeal model with variable epiglottis angles.
Data Brief
February 2025
Department of Biomedical Engineering, University of Massachusetts, 1 University Ave., Lowell, MA 01854, USA.
This dataset comprises a comprehensive collection of videos and images illustrating the fluid dynamics of swallowing and aspiration in a patient-specific pharyngolaryngeal model with varying epiglottis angles. The data also includes the physical properties of the fluids used, comprising dynamic viscosity, surface tension, and contact angle. Videos under varying swallowing conditions were collected to investigate the mechanisms underlying aspiration.
View Article and Find Full Text PDFOrange Peel : Development of A Mucoadhesive Nasal Spray with Antimicrobial and Anti-inflammatory Activity.
Pharmaceutics
November 2024
Beneficial Microbes Laboratory, Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy.
Due to the high frequency and severity of upper respiratory bacterial infections, probiotics could offer a new medical approach. We explored the antibacterial and anti-inflammatory properties of the new strain BIA and formulated a nasal spray. BIA was isolated from orange peel and taxonomically identified through 16S rRNA gene sequencing.
View Article and Find Full Text PDFMedia viscosity affects post-thaw ram sperm rheotactic behaviour.
Reprod Domest Anim
October 2024
Department of Biological Sciences, Faculty of Science and Engineering, University of Limerick, Limerick, Ireland.
The aim of this experiment was to assess the effect of media viscosity on ram sperm motility, kinematics and rheotaxis in vitro by using methylcellulose as a media thickener. Frozen-thawed semen of three rams was thawed and diluted in Tyrode's albumin lactate pyruvate (TALP) media supplemented with 0%, 0.1%, 0.
View Article and Find Full Text PDFThe effect of sulfonated reduced graphene oxide on the properties of ionic strength sensitive PEC film comprising protein/polysaccharides combined system.
Int J Biol Macromol
November 2024
Marmara University, Department of Chemical Engineering, Maltepe, 34854 Istanbul, Turkey. Electronic address:
Article Synopsis
- In the study, sulfonated reduced graphene oxide (SRGO) was added to a polyelectrolyte complex (PEC) made from gelatin, carboxymethyl cellulose, and hyaluronic acid to enhance its mechanical and conductive properties.
- Characterization techniques like FT-IR, SEM, and zeta potential confirmed the successful integration of SRGO, leading to improved performance and conductivity of the PEC films.
- The PEC films with SRGO displayed a polyelectrolyte behavior at different ionic strengths and pH levels, suggesting their potential as effective, controlled drug carriers for cancer treatments.
pH-responsive IPN beads of carboxymethyl konjac glucomannan and sodium carboxymethyl cellulose as a controlled release carrier for ibuprofen.
Int J Biol Macromol
October 2024
Higher School of Health, Polytechnic Institute of Guarda, Rua da Cadeia, 6300-307 Guarda, Portugal; REQUIMTE/LAQV, Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal. Electronic address:
The convergence of polymer and pharmaceutical sciences has advanced drug delivery systems significantly. Carbohydrate polymers, especially carboxymethylated ones, offer versatile benefits for pharmaceuticals. Interpenetrating polymer networks (IPNs) combine synthetic and natural polymers to enhance drug delivery.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!