Purpose: To determine whether the use of platelet-rich plasma gel (PRPG) affects magnetic resonance imaging (MRI) findings in the anterior cruciate ligament (ACL) graft during the first year after reconstruction.
Methods: A prospective single-blinded study of 50 ACL reconstructions in 50 patients was performed. In group A (study group) PRPG was added to the graft with a standardized technique, and in group B (control group) no PRPG was added. An MRI study was performed postoperatively between 3 and 9 months in group A and between 3 and 12 months in group B. The imaging analysis was performed in a blind protocol by the same radiologist.
Results: The mean heterogeneity score value at the time of MRI, assigned by the radiologist, was 1.14 in group A and 3.25 in group B. Both groups were comparable in terms of sex and age (P < .05). The mean time to obtain a completely homogeneous intra-articular segment in group A (PRPG added) was 177 days after surgery, and it was 369 days in group B. Using the quadratic predictive model, these findings show that group A (PRPG added) needed only 48% of the time group B required to achieve the same MRI image (P < .001).
Conclusions: ACL reconstruction with the use of PRPG achieves complete homogeneous grafts assessed by MRI, in 179 days compared with 369 days for ACL reconstruction without PRPG. This represents a time shortening of 48% with respect to ACL reconstruction without PRPG.
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http://dx.doi.org/10.1016/j.arthro.2009.06.030 | DOI Listing |
J Comput Chem
January 2025
Department of Chemistry, Computational and Theoretical Chemistry Group (CATCO), Southern Methodist University, Dallas, Texas, USA.
Histochem Cell Biol
November 2024
Department of Histology and Embryology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Türkiye.
Peripheral nerve injuries are commonly encountered in clinical practice. Peripheral nerve injuries most commonly result in serious problems affecting quality of life. The present study is designed to research the possible neuroprotective effects of Ankaferd blood stopper (ABS), platelet-rich plasma (PRP), and Momordica charantia (MC) on regeneration using unbiased stereological techniques.
View Article and Find Full Text PDFJ Assoc Physicians India
August 2024
Professor, Department of Surgery, Jawaharlal Nehru Medical College (DMIHER), Sawangi (Meghe), Maharashtra, India.
Introduction: Unlike conventional management protocols, like dressings, wound debridement, and skin grafting that do not facilitate healing, platelet-rich plasma (PRP) directly feeds growth factors to enhance wound healing.
Materials And Methods: An open randomized controlled trial with a sample size of 60 was carried out on patients with a wound surface area ≤10 × 10 cm with 30 participants in each. The PRP group (PRPG) was given autologous PRP using the infiltration technique, and the control group (CG) was treated using conventional dressings.
Regen Ther
June 2024
Sichuan Academy of Chinese Medicine Sciences, Chengdu, China.
Background: Intra-articular injection of platelet-rich plasma (PRP) or isometric contraction of quadriceps (ICQ) has shown positive effects in patients with knee osteoarthritis (KOA). However, the synergistic effect of combining PRP and ICQ intervention (joint intervention) on cartilage repair has not been validated. Thus, this study aimed to explore the reparative effects of joint intervention on cartilage in a KOA rat model.
View Article and Find Full Text PDFACS Appl Mater Interfaces
May 2024
Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
The combined effects of twisted intramolecular charge transfer (TICT) and aggregation-induced emission (AIE) phenomena have demonstrated a significant influence on excited-state chemistry. These combined TICT and AIE features have been extensively utilized to enhance photodynamic and photothermal therapy. Herein, we demonstrated the synergistic capabilities of TICT and AIE phenomena in the design of the photoremovable protecting group (PRPG), namely, NMe-Napy-BF.
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