AI Article Synopsis
- The review highlights the identification and traits of multipotent stromal cells found in human endometrium and decidua, emphasizing their isolation from both the basal endometrium and menstrual blood.
- These cells display key adult stem cell characteristics, including the ability to clone, self-renew, and differentiate into various cell types, and express specific surface markers (CD73, CD90, CD105).
- There is still uncertainty about whether these cells represent the same population due to observed differences in differentiation potential, raising the possibility that they might be influenced by hormonal and other factors.
Article Abstract
This review discusses the presence and characteristics of multipotent stromal cells in human endometrium and decidua. A number of research groups have reported the isolation and characterization of multipotent stromal cells from the basal layer of the endometrium, and in a single case just from the menstrual blood, i.e. the superficial functional layer. Similarly, multipotent pre-decidual stromal cells are isolated from early decidua and characterized accordingly. Multipotent endometrial stromal cells and multipotent decidual stromal cells are shown to express the basic features of adult stem cells, which are clonogenicity, self-renewal, a potential to differentiate into adipogenic, osteogenic, chrondrogenic, endothelial-like cells and a specific set of surface molecules (CD73, CD90 and CD105). So far, it is not clear whether the same population of multipotent stromal cells is isolated from the basal endometrium or early decidua because it has been shown that in some cases the differentiation potential of endometrial stromal cells is more restricted in comparison to the decidual stromal cells. It is reasonable to assume that it is one cell population under different control by hormonal, paracrine and autocrine factors. Thus far, the functions of these cells have not been convincingly revealed.
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| http://dx.doi.org/10.1016/j.rbmo.2009.12.011 | DOI Listing |
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