AI Article Synopsis
- C1q nephropathy is a rare kidney disease that can lead to nephrotic syndrome and is often related to minimal change disease or focal segmental glomerulosclerosis (FSGS).
- Disagreement among experts exists regarding whether C1q nephropathy is its own condition or part of the FSGS spectrum.
- Two African American patients with collapsing C1q nephropathy were found to carry a specific MYH9 gene variant, which is linked to severe kidney issues, suggesting that this type of C1q nephropathy may be part of the MYH9-related disease spectrum.
Article Abstract
C1q nephropathy is a rare kidney disease that can present with nephrotic syndrome and typically has the histologic phenotype of either minimal change disease or focal segmental glomerulosclerosis (FSGS). Disagreement exists about whether it is a distinct immune complex-mediated glomerulopathy or it resides in the spectrum of FSGS-minimal change disease. Two African American patients with C1q nephropathy histologically presenting as the collapsing variant of FSGS (collapsing C1q nephropathy) and rapid loss of kidney function were genotyped for polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9). Both cases were homozygous for the MYH9 E1 risk haplotype, the variant strongly associated with idiopathic FSGS, collapsing FSGS in human immunodeficiency virus-associated nephropathy, and focal global glomerulosclerosis (historically attributed to hypertensive nephrosclerosis). Collapsing C1q nephropathy with rapid progression to end-stage renal disease appears to reside in the MYH9-associated disease spectrum.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864358 | PMC |
| http://dx.doi.org/10.1053/j.ajkd.2009.10.060 | DOI Listing |
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