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Emerging Biochemical and Immunologic Mechanisms in the Pathogenesis of IgA Nephropathy.
Semin Nephrol
March 2025
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL.
IgA nephropathy is a mesangioproliferative glomerular disease with significant morbidity and mortality. Most patients with IgA nephropathy develop kidney failure in their lifetime, reducing their life expectancy by a decade. Since its first description in 1968, it has been established that kidneys of IgA nephropathy patients are injured as "innocent bystanders" by nephritogenic IgA1-containing immune complexes.
View Article and Find Full Text PDFEarly failure following pelvic exenteration: Who are the bad actors?
Surgeon
March 2025
Peter MacCallum Cancer Center, Melbourne, Australia; University of Melbourne, Australia.
Background: Pelvic exenteration for locally advanced (LARC) or recurrent rectal cancer (LRRC) is technically challenging with considerable morbidity for the patient. Though surgery can confer long-term survival in selected patients, early failure, defined as recurrence with one year, represents a major issue as both survival and quality of life are severely impacted. This study aims to highlight the "bad actors" associated with early failure.
View Article and Find Full Text PDFThe 'Health-2-Go' programme's impact on all-cause mortality and clinic utilisation for children 5 and under: a retrospective cohort analysis of an iCCM intervention in Ghana's Barekese Subdistrict.
BMJ Glob Health
March 2025
Department of Community Health, Ensign Global University, Kpong, Eastern Region, Ghana.
Introduction: The 'Health-2-Go' programme, which incorporates the integrated community case management strategy, aims to enhance healthcare access in rural Ghana by deploying trained and equipped community-based agents to manage the diagnosis and treatment of basic illness for children aged 5 and under. This study evaluates the intervention's impact on all-cause mortality and clinical healthcare utilisation among children 5 and under in the Barekese Subdistrict in the Atwima Nwabiagya North District of the Ashanti Region of Ghana.
Methods: A retrospective cohort study was conducted using data from 2530 children across nine communities exposed to Health-2-Go and six comparison communities with no Health-2-Go exposure.
Handling non-ignorable missing intimal hyperplasia data - Lessons from the VEST trial.
Contemp Clin Trials
March 2025
Center for Biostatistics, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America. Electronic address:
Non-ignorable missing data arise often in clinical trials. The VEST trial, a randomized, within-patient-controlled study, assessed the effect of an external scaffold for saphenous vein grafts on intimal hyperplasia (IH) one year after coronary artery bypass graft surgery. It was anticipated that approximately 13 % of grafts would be occluded and unsuitable for intravascular ultrasound, resulting in missing IH values at 1-year.
View Article and Find Full Text PDFNovel tailored very-high-power short-duration radiofrequency ablation around the esophagus guided by left atrial voltage.
J Cardiol
March 2025
Division of Cardiology, Osaka Rosai Hospital, Osaka, Japan. Electronic address:
Background: Very-high-power short-duration (vHPSD) radiofrequency (RF) ablation is expected to make shallow lesions and reduce collateral damage. This study investigated the power setting and quality of acute lesions performed by a modified vHPSD RF ablation guided by left atrial (LA) voltage around the esophagus.
Methods: A voltage map was obtained by an OCTARAY catheter (3-mm spacing) during pacing from the high right atrium.
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