AI Article Synopsis
- The study aimed to assess the plasma levels of Epstein Barr virus (EBV) DNA in children with EBV-related diseases and understand how these levels change after infection, as well as their link to disease severity.
- It involved 73 children with primary EBV infections and 18 children with severe EBV-enforced illnesses, utilizing real-time PCR to measure EBV DNA levels.
- Findings revealed that EBV DNA levels decreased over time in primary infections, while significantly higher levels were found in severe cases, indicating that monitoring EBV DNA can help evaluate the severity of the disease.
Article Abstract
Objective: To determine the plasma level of Epstein Barr virus (EBV) DNA in children with EBV associated diseases, and to investigate the dynamic changes of EBV DNA level after initial infection as well as the relationship between EBV DNA level and the diseases severity.
Methods: The subjects consisted of 73 children with primary EBV infection (infectious mononucleosis, pneumonia,etc.) and 18 children with severe EBV-associated diseases (chronic active EBV infection, hemophagocytic lymphohistiocytosis, etc.). The plasma EBV DNA level was detected by a real-time PCR assay.
Results: The plasma EBV DNA level decreased with the infection time in children with primary EBV infection. Two weeks after infection, plasma EBV DNA was almost undetectable. The positive rate of plasma EBV DNA in children with severe EBV associated diseases increased significantly when compared with that in children with primary EBV infection (89% vs 16%; p<0.05).
Conclusions: The level of EBV replication may be reduced with the infection time. Dynamic determination of blood EBV DNA is useful for the evaluation of disease severity in children with EBV infection.
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