Background And Aim: A connection between chronic mild stress and altered innervation in the skin of an atopic mouse strain, NC/Nga, was studied.
Material And Methods: We used three groups of mice, stressed control (SC, stressed but not immunized with a mite antigen), non-stressed eczematous (NSE, not stressed but immunized) and stressed eczematous (SE, stressed and immunized).
Results: There was a decrease of protein gene product (PGP) 9.5 positive nerve fibers in SE compared to SC mice, in both epidermis and dermis, also in SE compared to NSE mice. Also a decrease in growth associated protein (GAP)-43 positive nerve fibers was seen in SE compared to SC, in both epidermis and dermis.
Conclusion: Chronic mild stress in atopic mice leads to decreased innervation in eczematous lesions.
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