A highly efficient and practical route to 3,4-isopropylidene proline I, starting from (+)-3-carene, was developed. The three continuous stereocenters were constructed using the inherent chirality of the starting natural product 2. The overall yield for the 12-step synthesis is 34%. The optimized sequence leading to 1 has been successfully applied on a multigram scale, thereby establishing the practicality of this route.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jo9022759 | DOI Listing |
Publication Analysis
Top Keywords
facile efficient
4
efficient synthesis
4
synthesis 33-dimethyl
4
33-dimethyl isopropylidene
4
isopropylidene proline
4
proline +-3-carene
4
+-3-carene highly
4
highly efficient
4
efficient practical
4
practical route
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!