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Neurotransmitter-bound bestrophin channel structures reveal small molecule drug targeting sites for disease treatment.
Nat Commun
December 2024
Department of Ophthalmology, Columbia University, New York, NY, USA.
Best1 and Best2 are two members of the bestrophin family of anion channels critically involved in the prevention of retinal degeneration and maintenance of intraocular pressure, respectively. Here, we solved glutamate- and γ-aminobutyric acid (GABA)-bound Best2 structures, which delineate an intracellular glutamate binding site and an extracellular GABA binding site on Best2, respectively, identified extracellular GABA as a permeable activator of Best2, and elucidated the co-regulation of Best2 by glutamate, GABA and glutamine synthetase in vivo. We further identified multiple small molecules as activators of the bestrophin channels.
View Article and Find Full Text PDFA novel social-network-analysis-based approach for analyzing complex network of actors involved in accessibility of anti-cancer medications in Iran.
Health Res Policy Syst
December 2024
Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: The access to anti-cancer medications is influenced by policies formed via the convergence of various stakeholders. The aim of this study is to identify and analyse the stakeholders involved in formulating and implementing policies related to the accessibility of anti-cancer medications in Iran and their interactions that are relevant to the outcomes of these policies for the first time.
Methods: To achieve the objectives, a novel multistage social network analysis (SNA)-based approach that includes three phases is proposed.
A machine learning model to predict the risk factors causing feelings of burnout and emotional exhaustion amongst nursing staff in South Africa.
BMC Health Serv Res
December 2024
NuMIQ Research Focus Area, School of Nursing Science, North-West University, 11 Hoffman Street, Potchefstroom, South Africa.
Background: The demand for quality healthcare is rising worldwide, and nurses in South Africa are under pressure to provide care with limited resources. This demanding work environment leads to burnout and exhaustion among nurses. Understanding the specific factors leading to these issues is critical for adequately supporting nurses and informing policymakers.
View Article and Find Full Text PDFA ceramic microbridge microfluidic chip to study osteogenic differentiation of mesenchymal stem cells in bioactive ceramic immune microenvironment.
Bioact Mater
March 2025
College of Biomedical Engineering, Sichuan University, Chengdu, Sichuan, 610064, China.
Bioactive ceramics have been used in bone tissue repair and regeneration. However, because of the complex in vivo osteogenesis process, long cycle, and difficulty of accurately tracking, the mechanism of interaction between materials and cells has yet to be fully understood, hindering its development. The ceramic microbridge microfluidic chip system may solve the problem and provide an in vitro method to simulate the microenvironment in vivo.
View Article and Find Full Text PDFLanguage Dominance in Left-Handers: Unveiling Left Hemisphere Global Dominance With Specific Right Hemisphere Regional Dominance.
Cureus
November 2024
Department of Neurosurgery, Fukushima Medical University, Fukushima, JPN.
Introduction The degree to which each human brain hemisphere governs specific cognitive processes, such as language and handedness (the preference or dominance of one hand over the other), varies across individuals. Research has explored the nature of language laterality in left-handed (LH) individuals, indicating that left-hemisphere dominance for language is commonly observed across both left- and right-handed populations. Advanced imaging techniques, including functional transcranial Doppler sonography and fMRI, have revealed subtle differences in language lateralization between LH and right-handed (RH) individuals, particularly in semantic processing tasks.
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