AI Article Synopsis
- The review discusses new approaches and research about treating severe bleeding and coagulopathy, focusing on advanced therapies and ongoing studies.
- It highlights the effectiveness of massive transfusion protocols that provide immediate access to blood products and emphasize teamwork among healthcare providers to lower mortality rates.
- The article concludes that standardizing massive transfusion practices helps quickly restore normal blood clotting and significantly reduces early deaths.
Article Abstract
Purpose Of Review: To update readers on recent literature regarding treatment of coagulopathy for patients with life-threatening bleeding, highlighting emerging therapeutic options, controversial topics, and ongoing clinical trials.
Recent Findings: Massive transfusion protocols featuring immediate availability of blood products and multidisciplinary communication reduce mortality and conserve resources. There is a growing consensus that immediate administration of plasma and platelet units in a 1: 1: 1 ratio with red cell units reduces early mortality. Lyophilized and recombinant blood product components may have advantages over traditional blood products in certain clinical circumstances.
Summary: Massive transfusion protocols standardize treatment of the coagulopathy of massive bleeding, leading to rapid restoration of hemostasis and decrease in early mortality.
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| http://dx.doi.org/10.1097/ACO.0b013e32833723fe | DOI Listing |
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