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http://dx.doi.org/10.7863/jum.2010.29.2.325DOI Listing

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Article Synopsis
  • Surgery is the main treatment for primary hyperparathyroidism (PHPT), but MIBI-avid thyroid nodules can make it hard to find parathyroid adenomas.
  • A 49-year-old woman with hypercalcemia had imaging tests that indicated thyroid nodules, but further scans helped locate an adenoma better.
  • Combining various imaging methods like SPECT/CT and 4D CT is critical for successful surgery and improving results in patients with PHPT.
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Two-dimensional ultrasound (2DUS) echocardiography is the main noninvasive method used to evaluate cardiac function in animal models of myocardial infarction (MI). However, 2DUS echocardiography does not capture regional differences in cardiac contractility since it relies on planar images to estimate left ventricular (LV) geometry and global function. Thus, the current study was designed to evaluate the efficacy of a newly developed 4-dimensional ultrasound (4DUS) method in detecting cardiac functional differences between two models of MI, permanent ligation (PL), and ischemia/reperfusion (I/R) in rats.

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Purpose: Accurate preoperative localization is imperative to guide surgery in primary hyperparathyroidism (pHPT). It remains unclear which second-line imaging technique is most effective after negative first-line imaging. In this study, we compare the diagnostic effectiveness of [C]methionine PET/CT, [C]choline PET/CT, and four dimensional (4D)-CT head-to-head in patients with pHPT, to explore which of these imaging techniques to use as a second-line scan.

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4DCT in Discordant Parathyroid Adenoma Scans: Case Series and Meta-Analysis.

Laryngoscope

May 2024

Department of Otolaryngology, Head & Neck Surgery and Maxillofacial Surgery and The Department of Radiology and Imaging, Metabolism and Hypertension, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

Objective: To evaluate the accuracy of four-dimensional computerized-tomography (4DCT) for localizing parathyroid adenomas (PTAs) in cases with discordant or non-localizing ultrasonography (US) and Technetium-99 sestamibi (MIBI) scans.

Data Sources: Retrospective case series and systematic review.

Review Methods: A case series and meta-analysis of patients diagnosed with primary hyperparathyroidism and discordant US and MIBI scans who underwent 4DCT prior to surgery.

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