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We investigated the in vivo selective anti-inflammatory effect of L-156,602, which was first identified as a preferential delayed-type hypersensitivity-suppressant in our screening program and first reported to be a C5a antagonist. The agent most profoundly suppressed footpad edema 4 h after elicitation by concanavalin A (con A) and also caused a significantly impaired response after a further 20 h. Footpad edema induced by either serotonin, carrageenan or zymosan was not much influenced by the agent.
View Article and Find Full Text PDFEffects of L-156,602, a C5a receptor antagonist, on mouse experimental models of inflammation.
Biosci Biotechnol Biochem
December 1992
Noda Institute for Scientific Research, Chiba, Japan.
L-156,602, a C5a receptor antagonist, was found as an immunosuppressant with preferential effects on delayed-type hypersensitivity (DTH) in our screening program and it was shown that L-156,602 suppressed the efferent phase of DTH. Here, we tested its effects on experimental models of inflammation induced in mice. L-156,602 did not suppress serotonin- and carrageenan- induced inflammation while it completely suppressed concanavalin A-induced inflammation 4 h after elicitation.
View Article and Find Full Text PDFPreferential suppression of delayed-type hypersensitivity by L-156,602, a C5a receptor antagonist.
Biosci Biotechnol Biochem
October 1992
Department of Agricultural Chemistry, University of Tokyo, Japan.
In the course of our screening for in vivo immunomodulating substances in which sheep red blood cells (SRBC) and heat-killed Brucella abortus cells (thymus dependent and independent antigens, respectively) for antibody production assays, and trinitrobenzene sulfonic acid (TNBS) for delayed-type hypersensitivity (DTH) assay were adopted as antigens, we detected a DTH-specific suppressive activity. The producing organism was isolated from a soil sample collected in Ushiku City, Ibaraki, Japan and identified with Streptomyces sp. A1502 (FERM P-12448).
View Article and Find Full Text PDFL-156,602, a C5a antagonist with a novel cyclic hexadepsipeptide structure from Streptomyces sp. MA6348. Fermentation, isolation and structure determination.
J Antibiot (Tokyo)
February 1991
Merck Sharp & Dohme Research Laboratories, Rahway, N.J. 07065.
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