Assessment of treatments in children with cerebral palsy has been well developed, especially in the gait laboratory. However, the prerequisite for walking is adequate postural control. We hypothesize that a treatment of an equinus deformity should improve postural control. Balance control was assessed by static posturography on the Balance Master. Nine diplegic children, six girls and three boys, participated in the study. Assessment was conducted before and after treatment of the equinus deformity. Two static tests (Weight Bearing Squat and the modified Clinical Test for Sensory Interaction on Balance), and two dynamic balance tests (Limits of Stability and Rhythmic Weight Shift) were performed on the Balance Master. After treatment, mean weight-bearing asymmetry measured by the Weight Bearing Squat was significantly improved at 30 degrees of knee flexion. In the modified Clinical Test for Sensory Interaction on Balance, there was a significant improvement in two conditions (eyes closed on foam surface and the composite score). The Limits of Stability was very difficult to perform for almost all the children. In the Rhythmic Weight Shift, mean directional control improved significantly in three conditions (left/right weight shift at 1 s of transition, front/back weight shift at 2 s of transition and the composite score of the front/back direction). The Balance Master offers the opportunity for an objective and easy assessment of postural control in children with cerebral palsy.
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http://dx.doi.org/10.1097/BPB.0b013e32832e957a | DOI Listing |
Clin Transl Sci
January 2025
College of Pharmacy, Daegu Catholic University, Gyeongsan, Korea.
Monoclonal antibodies (mAbs) are critical components in the therapeutic landscape, but their dosing strategies often evolve post-approval as new data emerge. This review evaluates post-marketing label changes in dosing information for FDA-approved mAbs from January 2015 to September 2024, with a focus on both initial and extended indications. We systematically analyzed dosing modifications, categorizing them into six predefined groups: Dose increases or decreases, inclusion of new patient populations by body weight or age, shifts from body weight-based dosing to fixed regimens, and adjustments in infusion rates.
View Article and Find Full Text PDFWaste Manag
January 2025
Guangdong Provincial Key Lab of Agro-animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China; Guangxi Key Laboratory of Sericulture Ecology and Applied Intelligent Technology/ Guangxi Collaborative Innovation Center of Modern Sericulture and Silk, Hechi University, Hechi 546300, China. Electronic address:
Sericulture waste poses significant challenges to industrial and environmental safety. Black soldier fly larvae (BSFL) offer a promising solution for organic waste management by converting it into insect protein. This study aimed to develop a microbial fermented method for utilizing sericulture waste to feed BSFL and explore the underlying mechanisms.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
January 2025
School of Psychology and Public Health, La Trobe University, Melbourne, Australia.
Purpose: Prolonged exposure to broadband light with a short-wavelength (blue) or long-wavelength (orange/red) bias is known to impact eye growth and refraction, but the mechanisms underlying this response are unknown. Thus, the present study investigated the effects of broadband blue and orange lights with well-differentiated spectrums on refractive development and global flash electroretinography (gfERG) measures of retinal function in the chick myopia model.
Methods: Chicks were raised for 4 days with monocular negative lenses, or no lens, under blue, orange, or white light.
Unlabelled: Neurophysiology studies propose that predictive coding is implemented via alpha/beta (8-30 Hz) rhythms that prepare specific pathways to process predicted inputs. This leads to a state of relative inhibition, reducing feedforward gamma (40-90 Hz) rhythms and spiking to predictable inputs. We refer to this model as predictive routing.
View Article and Find Full Text PDFMethodsX
June 2025
Department of Mathematical Sciences, Universiti Teknologi Malaysia, Johor Bahru, Malaysia.
PM2.5 air pollution poses significant health risks, particularly in urban areas such as Jakarta, where concentrations frequently surpass acceptable levels due to rapid urbanization. This study addresses autocorrelation in air quality data and evaluates the monitoring performance of XGBoost and Support Vector Regression (SVR) models using Individual and Exponentially Weighted Moving Average (EWMA) Charts.
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