The literature contains rare reports on anesthetic maintenance in non-cardiac operations in patients with dilated cardiomyopathy and an ejection fraction of less than 30%. Life-saving non-cardiosurgical interventions are performed in these patients since they are associated with a high risk for perioperative complications and fatal outcome. In these cases, anesthetic maintenance is performed with inotropic support; there is frequently a need to use a pacemaker, a cardioverter, or a LV assist device. The paper describes the first case of xenon anesthesia in a patient with dilated cardiomyopathy with an ejection fraction of less than 30% and rapidly progressing spinal cord tumor. The ability of xenon to maintain stable blood pressure and cardiac contractility could prevent perioperative infusion of inotropic agents. In 60-70% of cases, the maximum alveolar concentration of xenon enables anesthesia to be virtually performed as monoanesthesia without adding the anesthetics lowering cardiac contractility; the low blood-gas distribution coefficient ensures early emergence from anesthesia with early extubation and activation of a patient. In the author's opinion, xenon anesthesia has every reason to become the method of choice as anesthetic maintenance in patients with severe cardiac dysfunction.

Download full-text PDF

Source

Publication Analysis

Top Keywords

xenon anesthesia
12
dilated cardiomyopathy
12
anesthetic maintenance
12
anesthesia patient
8
patient dilated
8
spinal cord
8
cardiomyopathy ejection
8
ejection fraction
8
fraction 30%
8
cardiac contractility
8

Similar Publications

Background: Administration of conventional anaesthetic agents is associated with changes in electroencephalogram (EEG) oscillatory dynamics, including a reduction in the peak alpha frequency. Computational models of neurones can reproduce such phenomena and are valuable tools for investigating their underlying mechanisms. We hypothesised that EEG data acquired during xenon anaesthesia in humans would show similar changes in peak alpha frequency and that computational neuronal models of recognised cellular actions of xenon would be consistent with the observed changes.

View Article and Find Full Text PDF

The Role of GABA Receptors in Anesthesia and Sedation: An Updated Review.

CNS Drugs

January 2025

Department of Anesthesiology, Jefferson Surgical Center Endoscopy, Sidney Kimmel Medical College, Jefferson Health, 111 S 11th Street, #7132, Philadelphia, PA, 19107, USA.

GABA (γ-aminobutyric acid) receptors are constituents of many inhibitory synapses within the central nervous system. They are formed by 5 subunits out of 19 various subunits: α1-6, β1-3, γ1-3, δ, ε, θ, π, and ρ1-3. Two main subtypes of GABA receptors have been identified, namely GABAA and GABAB.

View Article and Find Full Text PDF

Xenon gas has significant advantages over conventional general anesthetic agents but its use has been limited by the cost associated with its production. Xenon also has significant potential for medical use in the treatment of acquired brain injuries and for mental health disorders. As the demand for xenon gas from other industries increases, the costs associated with its medical use are only likely to increase.

View Article and Find Full Text PDF

Photosensitivity is characterized by an abnormal skin reaction to light that causes various adverse skin reactions such as blistering, redness, and inflammation. Photosensitivity may also depend on the wavelength of the light as minor changes affect different layers of the skin. During surgical procedures, many different types of light are used with a range of wavelengths.

View Article and Find Full Text PDF

Anaesthetics disrupt complex I-linked respiration and reverse the ATP synthase.

Biochim Biophys Acta Bioenerg

January 2025

Centre for Life's Origins and Evolution (CLOE), Department of Genetics, Evolution and Environment, University College London, United Kingdom of Great Britain and Northern Ireland. Electronic address:

The mechanism of volatile general anaesthetics has long been a mystery. Anaesthetics have no structural motifs in common, beyond lipid solubility, yet all exert a similar effect. The fact that the inert gas xenon is an anaesthetic suggests their common mechanism might relate to physical rather than chemical properties.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!