AI Article Synopsis
- The study aimed to investigate the effects of a 6.0% carboxymethylcellulose (CMC) injection on the oculomotor system of rabbits, focusing on changes in movement, durability of effects, and potential inflammation.
- Twenty-five New Zealand rabbits were divided into groups receiving either CMC or saline injections, with various volumes administered to assess differences in force required for eye movements and resultant changes in intraocular pressure.
- Findings indicated that CMC modified eye movement dynamics in the rabbits, with some groups experiencing increased force and histological signs of inflammation and fibrosis, suggesting a complex interaction between CMC’s effects and any inflammatory responses.
Article Abstract
Purpose: To determine the effects of 6.0% carboxymethylcellulose (CMC) in modifying the oculomotor system of rabbits by means of viscoelastic action forces, the durability of this effect and possible inflammatory reaction.
Methods: Twenty-five New Zealand rabbits were divided into two experimental groups: one treated with a peribulbar injection of 6.0% CMC and a control group submitted to peribulbar injection of 3.0 cc of physiological saline. The group submitted to peribulbar CMC injection was divided into four subgroups respectively receiving the following volumes: 1.0, 1.5, 2.0 and 3.0 cc. The force needed to promote tangential adduction dislocations, external ophthalmologic signs and intraocular pressure were evaluated. The animals were sacrificed on the 60th day after the injection for histological analysis.
Results: The mean force detected 60 days after the injection of 6.0% CMC was lower in the 1.0 treated subgroup and higher in the 1.5, 2.0 and 3.0 treated subgroups relative to the force before injection. Histological analysis revealed histiocytic infiltration with fibrosis in the subgroups in which there was an increase in force and the presence of CMC in periocular tissues.
Conclusions: 6.0% CMC acted as a modifier of the oculomotor system of rabbits, facilitating or impairing movements. It was not possible to conclude whether the increase in force occurred as a consequence of the inflammatory process alone or of the sum of inflammation and a possible viscous attrition provoked by CMC.
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| http://dx.doi.org/10.1590/s0004-27492009000600011 | DOI Listing |
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